[HTML][HTML] Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
Background Plasma insulin levels are predominantly the product of the morphological mass
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
of insulin producing beta cells in the pancreatic islets of Langerhans and the functional …
Structural similarities and differences between the human and the mouse pancreas
Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …
research are typically extrapolated to humans, it is important to understand both similarities …
[HTML][HTML] Networks behind the morphology and structural design of living systems
Technological advances in imaging techniques and biometric data acquisition have enabled
us to apply methods of network science to study the morphology and structural design of …
us to apply methods of network science to study the morphology and structural design of …
Stem cell therapies for treating diabetes: progress and remaining challenges
Restoration of insulin independence and normoglycemia has been the overarching goal in
diabetes research and therapy. While whole-organ and islet transplantation have become …
diabetes research and therapy. While whole-organ and islet transplantation have become …
Organisation of the human pancreas in health and in diabetes
For much of the last century, our knowledge regarding the pancreas in type 1 and type 2
diabetes was largely derived from autopsy studies of individuals with these disorders or …
diabetes was largely derived from autopsy studies of individuals with these disorders or …
Integrating the inputs that shape pancreatic islet hormone release
GM Noguchi, MO Huising - Nature Metabolism, 2019 - nature.com
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …
their support cells, which together tightly control blood glucose homeostasis. Changes in …
A predictive computational platform for optimizing the design of bioartificial pancreas devices
The delivery of encapsulated islets or stem cell-derived insulin-producing cells (ie,
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
bioartificial pancreas devices) may achieve a functional cure for type 1 diabetes, but their …
Regional differences in islet distribution in the human pancreas-preferential beta-cell loss in the head region in patients with type 2 diabetes
While regional heterogeneity in islet distribution has been well studied in rodents, less is
known about human pancreatic histology. To fill gaps in our understanding, regional …
known about human pancreatic histology. To fill gaps in our understanding, regional …
Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …
Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing
Pancreatic β cell function is compromised in diabetes and is typically assessed by
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …
measuring insulin secretion during glucose stimulation. Traditionally, measurement of …