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Implications of plasma thiol redox in disease
Thiol groups are crucially involved in signaling/homeostasis through oxidation, reduction,
and disulphide exchange. The overall thiol pool is the resultant of several individual pools of …
and disulphide exchange. The overall thiol pool is the resultant of several individual pools of …
[HTML][HTML] The protective role of heme oxygenase-1 in atherosclerotic diseases
Y Kishimoto, K Kondo, Y Momiyama - International journal of molecular …, 2019 - mdpi.com
Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to
generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently …
generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently …
Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases
Bilirubin, the principal tetrapyrrole, bile pigment and catabolite of haem, is an emerging
biomarker of disease resistance, which may be related to several recently documented …
biomarker of disease resistance, which may be related to several recently documented …
Heme oxygenase-1: a metabolic nike
Significance: Heme degradation, which was described more than 30 years ago, is still very
actively explored with many novel discoveries on its role in various disease models every …
actively explored with many novel discoveries on its role in various disease models every …
Bilirubin, a cardiometabolic signaling molecule
Hinds and Stec Bilirubin Signaling 789 protein, which results in enhanced phosphorylation,
transactivation, and DNA binding to PPAR response elements in promoters or enhancers of …
transactivation, and DNA binding to PPAR response elements in promoters or enhancers of …
Bile acids and bilirubin role in oxidative stress and inflammation in Cardiovascular diseases
Bile acids (BAs) and bilirubin, primarily known for their role in lipid metabolism and as heme
catabolite, respectively, have been found to have diverse effects on various physiological …
catabolite, respectively, have been found to have diverse effects on various physiological …
Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation
Obesity-induced endoplasmic reticulum (ER) stress causes chronic inflammation in adipose
tissue and steatosis in the liver, and eventually leads to insulin resistance and type 2 …
tissue and steatosis in the liver, and eventually leads to insulin resistance and type 2 …
Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and resha** the immune system
Atherosclerosis is a chronic inflammatory disease caused mainly by lipid accumulation and
excessive inflammatory immune response. Although the lipid-lowering and cardioprotective …
excessive inflammatory immune response. Although the lipid-lowering and cardioprotective …
Bilirubin and beyond: a review of lipid status in Gilbert's syndrome and its relevance to cardiovascular disease protection
Gilbert's syndrome (GS) is characterized by a benign, mildly elevated bilirubin concentration
in the blood. Recent reports show clear protection from cardiovascular disease in this …
in the blood. Recent reports show clear protection from cardiovascular disease in this …
Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα
Gilbert's syndrome in humans is derived from a polymorphism (TA repeat) in the hepatic
UGT1A1 gene that results in decreased conjugation and increased levels of unconjugated …
UGT1A1 gene that results in decreased conjugation and increased levels of unconjugated …