Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays

RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …

Recent Advances in the Discovery of Bioactive Metabolites from Xylaria Hill ex Schrank

SK Deshmukh, KR Sridhar, S Saxena… - Biology, Cultivation and …, 2022 - Springer
Xylaria is the largest genus of the family Xylariaceae (Xylariales, Sordariomycetes) and
presently consists of ca. 300 accepted species of stromatic pyrenomycetes. They are …

Application of optimized and validated agar overlay TLC–bioautography assay for detecting the antimicrobial metabolites of pharmaceutical interest

BR Nuthan, D Rakshith… - Journal of …, 2020 - academic.oup.com
The agar overlay TLC–bioautography is one of the crucial methods for simultaneous in situ
detection and separation of antimicrobial metabolites of pharmaceutical interest. The main …

Eco-toxicity of water, soil, and sediment from agricultural areas of Kilombero Valley Ramsar wetlands, Tanzania

SF Materu, S Heise - Ecosystem health and sustainability, 2019 - Taylor & Francis
This study was conducted in the KVRS to; evaluate the seasonal eco-toxicity of water, soil
and sediment samples; establish the suitability of using temperate biotest batteries in …

Ecotoxicological assessment of brownfield soil by bioassay

TV Bardina, MV Chugunova, VV Kulibaba… - … in Understanding Soil …, 2022 - Springer
The study provides a comparative assessment of the ecotoxicity of brownfield soil
contaminated due to past environmental damage in the Northwestern region of the Russian …

[HTML][HTML] TLC directed isolation and in silico analysis of antimicrobial metabolite from Nigrospora sphaerica inhabiting Croton bonplandianus Baill

NC Mohana, D Rakshith, KP Ramesha… - South African Journal of …, 2021 - Elsevier
TLC-bioautography amalgamated with hyphenated spectroscopy aid in precise in situ
detection of secondary metabolites with pharmaceutical significance. TLC bioautography …

Bioassay guided fractionation of bioactive metabolite from Corynascus verrucosus inhabiting Croton bonplandianus Baill

NC Mohana, D Rakshith, HCY Rao, KP Ramesha… - Process …, 2020 - Elsevier
Mycoendophytes have been a promising source of bioactive metabolites for new
developments in pharmaceuticals and industrial relevance. During the screening of …

Chemogenomics driven discovery of endogenous polyketide anti-infective compounds from endosymbiotic Emericella variecolor CLB38 and their RNA secondary …

HC Yashavantha Rao, D Rakshith, BP Harini… - Plos one, 2017 - journals.plos.org
In the postgenomic era, a new strategy for chemical dereplication of polyketide anti-infective
drugs requires novel genomics and chromatographic strategies. An endosymbiotic fungal …

[PDF][PDF] Bioactive natural products from marine macroalgal endophytes from the Bay of Fundy, Canada

A Flewelling - 2017 - unbscholar.lib.unb.ca
We are approaching a time where antimicrobial drugs may no longer be effective due to the
growing global antimicrobial resistance crisis, coupled with the lack of antimicrobial drug …

Evaluation of Bacillus biocontrol potential through the lens of secondary metabolite diversity in genomic, enzymatic, and chemical space

MJ Alam - 2022 - search.proquest.com
Global food security is under threat by plant-pathogenic oomycetes and fungi. The overuse
and misuse of pesticides against such pathogens triggers fungicide resistance and long …