Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays
RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …
therefore are attractive sources for new leads in drug discovery. This review describes drug …
Recent Advances in the Discovery of Bioactive Metabolites from Xylaria Hill ex Schrank
Xylaria is the largest genus of the family Xylariaceae (Xylariales, Sordariomycetes) and
presently consists of ca. 300 accepted species of stromatic pyrenomycetes. They are …
presently consists of ca. 300 accepted species of stromatic pyrenomycetes. They are …
Application of optimized and validated agar overlay TLC–bioautography assay for detecting the antimicrobial metabolites of pharmaceutical interest
BR Nuthan, D Rakshith… - Journal of …, 2020 - academic.oup.com
The agar overlay TLC–bioautography is one of the crucial methods for simultaneous in situ
detection and separation of antimicrobial metabolites of pharmaceutical interest. The main …
detection and separation of antimicrobial metabolites of pharmaceutical interest. The main …
Eco-toxicity of water, soil, and sediment from agricultural areas of Kilombero Valley Ramsar wetlands, Tanzania
This study was conducted in the KVRS to; evaluate the seasonal eco-toxicity of water, soil
and sediment samples; establish the suitability of using temperate biotest batteries in …
and sediment samples; establish the suitability of using temperate biotest batteries in …
Ecotoxicological assessment of brownfield soil by bioassay
TV Bardina, MV Chugunova, VV Kulibaba… - … in Understanding Soil …, 2022 - Springer
The study provides a comparative assessment of the ecotoxicity of brownfield soil
contaminated due to past environmental damage in the Northwestern region of the Russian …
contaminated due to past environmental damage in the Northwestern region of the Russian …
[HTML][HTML] TLC directed isolation and in silico analysis of antimicrobial metabolite from Nigrospora sphaerica inhabiting Croton bonplandianus Baill
NC Mohana, D Rakshith, KP Ramesha… - South African Journal of …, 2021 - Elsevier
TLC-bioautography amalgamated with hyphenated spectroscopy aid in precise in situ
detection of secondary metabolites with pharmaceutical significance. TLC bioautography …
detection of secondary metabolites with pharmaceutical significance. TLC bioautography …
Bioassay guided fractionation of bioactive metabolite from Corynascus verrucosus inhabiting Croton bonplandianus Baill
Mycoendophytes have been a promising source of bioactive metabolites for new
developments in pharmaceuticals and industrial relevance. During the screening of …
developments in pharmaceuticals and industrial relevance. During the screening of …
Chemogenomics driven discovery of endogenous polyketide anti-infective compounds from endosymbiotic Emericella variecolor CLB38 and their RNA secondary …
HC Yashavantha Rao, D Rakshith, BP Harini… - Plos one, 2017 - journals.plos.org
In the postgenomic era, a new strategy for chemical dereplication of polyketide anti-infective
drugs requires novel genomics and chromatographic strategies. An endosymbiotic fungal …
drugs requires novel genomics and chromatographic strategies. An endosymbiotic fungal …
[PDF][PDF] Bioactive natural products from marine macroalgal endophytes from the Bay of Fundy, Canada
A Flewelling - 2017 - unbscholar.lib.unb.ca
We are approaching a time where antimicrobial drugs may no longer be effective due to the
growing global antimicrobial resistance crisis, coupled with the lack of antimicrobial drug …
growing global antimicrobial resistance crisis, coupled with the lack of antimicrobial drug …
Evaluation of Bacillus biocontrol potential through the lens of secondary metabolite diversity in genomic, enzymatic, and chemical space
MJ Alam - 2022 - search.proquest.com
Global food security is under threat by plant-pathogenic oomycetes and fungi. The overuse
and misuse of pesticides against such pathogens triggers fungicide resistance and long …
and misuse of pesticides against such pathogens triggers fungicide resistance and long …