[HTML][HTML] The 2021 WHO classification of lung tumors: impact of advances since 2015

AG Nicholson, MS Tsao, MB Beasley… - Journal of Thoracic …, 2022 - Elsevier
Abstract The 2021 WHO Classification of Thoracic Tumours was published earlier this year,
with classification of lung tumors being one of the chapters. The principles remain those of …

Challenge and countermeasures for EGFR targeted therapy in non-small cell lung cancer

X Tian, T Gu, MH Lee, Z Dong - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Lung cancer causes the highest mortality compared to other cancers in the world according
to the latest WHO reports. Non-small cell lung cancer (NSCLC) contributes about 85% of …

Sintilimab plus chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer with disease progression after EGFR tyrosine-kinase inhibitor …

S Lu, L Wu, H Jian, Y Cheng, Q Wang… - The Lancet …, 2023 - thelancet.com
Background In the first interim analysis of the ORIENT-31 trial, compared with chemotherapy
alone, sintilimab plus bevacizumab biosimilar IBI305 plus chemotherapy (pemetrexed and …

Lung cancer in never smokers—the East Asian experience

F Zhou, C Zhou - Translational lung cancer research, 2018 - pmc.ncbi.nlm.nih.gov
Approximately one third of all lung cancer patients in East Asia are never-smokers.
Furthermore, the proportion of lung cancer in never smokers (LCINS) has been increasing …

Genomic landscape of atypical adenomatous hyperplasia reveals divergent modes to lung adenocarcinoma

S Sivakumar, FAS Lucas, TL McDowell, W Lang… - Cancer …, 2017 - aacrjournals.org
There is a dearth of knowledge about the pathogenesis of premalignant lung lesions,
especially for atypical adenomatous hyperplasia (AAH), the only known precursor for the …

Exon 14 deleted MET receptor as a new biomarker and target in cancers

AB Cortot, Z Kherrouche… - Journal of the …, 2017 - academic.oup.com
Inhibitors of the receptor tyrosine kinase (RTK) MET have been ineffective at treating cancer,
possibly because of lack of knowledge that would allow selection of tumors likely to respond …

Clinicopathological implications of MET exon 14 mutations in non-small cell lung cancer–A systematic review and meta-analysis

HG Vuong, ATN Ho, AMA Altibi, T Nakazawa, R Katoh… - Lung Cancer, 2018 - Elsevier
MET exon 14 mutation is an uncommon genomic alteration in non-small cell lung cancer
(NSCLC). This meta-analysis aimed at investigating the clinicopathological and prognostic …

New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment

P Wang, S Sun, S Lam, WW Lockwood - Journal of Translational Medicine, 2023 - Springer
Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …