Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response
DR Wang, XL Wu, YL Sun - Signal transduction and targeted therapy, 2022 - nature.com
Cancers are highly complex diseases that are characterized by not only the overgrowth of
malignant cells but also an altered immune response. The inhibition and reprogramming of …
malignant cells but also an altered immune response. The inhibition and reprogramming of …
Therapeutic targeting of tumour myeloid cells
ST Barry, DI Gabrilovich, OJ Sansom… - Nature Reviews …, 2023 - nature.com
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
accumulation of tumour-modified myeloid cells derived from monocytes or neutrophils …
Chromosomal instability as a driver of cancer progression
Chromosomal instability (CIN) refers to an increased propensity of cells to acquire structural
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
and numerical chromosomal abnormalities during cell division, which contributes to tumour …
MACHETE identifies interferon-encompassing chromosome 9p21. 3 deletions as mediators of immune evasion and metastasis
The most prominent homozygous deletions in cancer affect chromosome 9p21. 3 and
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis …
JAK: not just another kinase
The JAK/STAT axis is implicated in cancer, inflammation, and immunity. Numerous
cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK 2) …
cytokines/growth factors affect JAK/STAT signaling. JAKs (JAK1, JAK2, JAK3, and TYK 2) …
Somatic 9p24.1 alterations in HPV– head and neck squamous cancer dictate immune microenvironment and anti-PD-1 checkpoint inhibitor activity
Somatic copy number alterations (SCNAs), generally losses containing interferons and
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …
interferon-pathway genes, many on chromosome 9p, predict immune-cold, immune …
Nivolumab and ipilimumab in recurrent or refractory cancer of unknown primary: a phase II trial
M Pouyiourou, BN Kraft, T Wohlfromm, M Stahl… - Nature …, 2023 - nature.com
Cancer of unknown primary has a dismal prognosis, especially following failure of platinum-
based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which …
based chemotherapy. 10-20% of patients have a high tumor mutational burden (TMB), which …
Late-stage metastatic melanoma emerges through a diversity of evolutionary pathways
Understanding the evolutionary pathways to metastasis and resistance to immune-
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
checkpoint inhibitors (ICI) in melanoma is critical for improving outcomes. Here, we present …
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance
Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …
methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in …