Intrinsic luminescence from nonaromatic biomolecules
Y Wang, Z Zhao, WZ Yuan - ChemPlusChem, 2020 - Wiley Online Library
Novel emitters that do not contain traditional chromophores but only electron‐rich moieties
(eg amine, C= O,− OH, ether, and imide), which are classified as nonconventional …
(eg amine, C= O,− OH, ether, and imide), which are classified as nonconventional …
Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues
LW Simpson, TA Good, JB Leach - Biotechnology advances, 2020 - Elsevier
In the biological milieu of a cell, soluble crowding molecules and rigid confined
environments strongly influence whether the protein is properly folded, intrinsically …
environments strongly influence whether the protein is properly folded, intrinsically …
ThX–a next-generation probe for the early detection of amyloid aggregates
Neurodegenerative diseases such as Alzheimer's and Parkinson's are associated with
protein misfolding and aggregation. Recent studies suggest that the small, rare and …
protein misfolding and aggregation. Recent studies suggest that the small, rare and …
Fluorescence self-quenching from reporter dyes informs on the structural properties of amyloid clusters formed in vitro and in cells
The characterization of the aggregation kinetics of protein amyloids and the structural
properties of the ensuing aggregates are vital in the study of the pathogenesis of many …
properties of the ensuing aggregates are vital in the study of the pathogenesis of many …
Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer's disease
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. There is no
test for its definitive diagnosis in routine clinical practice. Although phase III clinical trials …
test for its definitive diagnosis in routine clinical practice. Although phase III clinical trials …
Detecting beta-amyloid glycation by intrinsic fluorescence-Understanding the link between diabetes and Alzheimer's disease
We monitor early stages of beta-amyloid (Aβ 1–40) aggregation, one of the key processes
leading to Alzheimer's disease (AD), in the presence of high glucose concentrations by …
leading to Alzheimer's disease (AD), in the presence of high glucose concentrations by …
Engineering of a fluorescent protein for a sensing of an intrinsically disordered protein through transition in the chromophore state
Intrinsically disordered proteins (IDPs) not only play important roles in biological processes
but are also linked with the pathogenesis of various human diseases. Specific and reliable …
but are also linked with the pathogenesis of various human diseases. Specific and reliable …
Impact of four common hydrogels on amyloid-β (Aβ) aggregation and cytotoxicity: implications for 3d models of Alzheimer's disease
LW Simpson, GL Szeto, H Boukari, TA Good… - ACS …, 2020 - ACS Publications
The physiochemical properties of hydrogels utilized in 3D culture can be used to modulate
cell phenotype and morphology with a striking resemblance to cellular processes that occur …
cell phenotype and morphology with a striking resemblance to cellular processes that occur …
Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects
Alzheimer's disease (AD) is the most common form of dementia and is associated with the
accumulation of amyloid-β (Aβ), a peptide whose aggregation has been associated with …
accumulation of amyloid-β (Aβ), a peptide whose aggregation has been associated with …
Tyrosine photophysics during the early stages of β-amyloid aggregation leading to Alzheimer's
OJ Rolinski, T Wellbrock, DJS Birch… - The journal of physical …, 2015 - ACS Publications
We have monitored the formation of toxic β-amyloid oligomers leading to Alzheimer's
disease by detecting changes in the fluorescence decay of intrinsic tyrosine. A new …
disease by detecting changes in the fluorescence decay of intrinsic tyrosine. A new …