Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling
processes that are critical for differentiation and proliferation. Not surprisingly, loss of …

SWI/SNF complexes are among the most studied ATP-dependent chromatin remodeling
complexes, mostly due to their critical role in coordinating chromatin architecture and gene …

Although mammalian SWI/SNF chromatin remodeling complexes have been well
established to play important role in transcription, their role in DNA repair has remained …

During DNA replication, transcription and DNA repair in eukaryotes, the cellular machineries
performing these tasks need to gain access to the DNA that is packaged into chromatin in …

Each day a cell must face a constant onslaught of DNA lesions. Although we tend to worry
most about environmental sources of DNA damage (eg, chemical agents, UV radiation …

DNA damage response, DNA repair and genomic instability have been under study for their
role in tumor initiation and progression for many years now. More recently, next-generation …

Although solar light is indispensable for the functioning of plants, this environmental factor
may also cause damage to living cells. Apart from the visible range, including wavelengths …

Cisplatin is a mainstay of systemic therapy for a variety of cancers, such as lung cancer,
head and neck cancer, and ovarian cancer. However, resistance to cisplatin represents one …

Reactive oxygen species (ROS) production is one of the earliest responses when plants
percept pathogens and acts as antimicrobials to block pathogen entry. However, whether …