C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

Smoking increases mortality from all causes and has a crucial role in atherosclerotic
cardiovascular disease (ASCVD). Active smoking and secondhand smoke exposure …

Background Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the
presence of an expanded somatic blood-cell clone in persons without other hematologic …

The remarkable plasticity and plethora of biological functions performed by macrophages
have enticed scientists to study these cells in relation to atherosclerosis for> 50 years, and …

Atherosclerosis is the underlying cause of heart attack and stroke. Early observations that
cholesterol is a key component of arterial plaques gave rise to the cholesterol hypothesis for …

Atherosclerosis is a long-term, chronic inflammatory disease of the vessel wall leading to the
formation of occlusive or rupture-prone lesions in large arteries. Complications of …

Chemokines are small proteins that control several tissue functions, including cell
recruitment and activation under homeostatic and inflammatory conditions. CXCL8 …

Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an
ongoing inflammatory response. Recent advances in basic science have established a …

Atherosclerosis is an inflammatory disease. Because high plasma concentrations of
cholesterol, in particular those of low-density lipoprotein (LDL) cholesterol, are one of the …

Aims Chemokine-mediated monocyte infiltration into the damaged heart represents an initial
step in inflammation during cardiac remodelling. Our recent study demonstrates a central …