Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

CM Rohr, DJ Sprague, SK Park, NJ Malcolm… - Proceedings of the …, 2023 - pnas.org
The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other
infections caused by parasitic flatworms. A schistosome target for PZQ was recently …

Pharmacokinetic variability of anthelmintics: implications for the treatment of neurocysticercosis

H Jung-Cook - Expert Review of Clinical Pharmacology, 2012 - Taylor & Francis
Human neurocysticercosis is a severe disease caused by the installation of Taenia solium
larvae in the CNS. A wide variety of clinical manifestations are related to neurocysticercosis …

What about the Cytoskeletal and Related Proteins of Tapeworms in the Host's Immune Response? An Integrative Overview

DG Ríos-Valencia, J Ambrosio, R Tirado-Mendoza… - Pathogens, 2023 - mdpi.com
Recent advances have increased our understanding of the molecular machinery in the
cytoskeleton of mammalian cells, in contrast to the case of tapeworm parasites, where …

Cassia alata L: potential role as anthelmintic agent against Hymenolepis diminuta

S Kundu, S Roy, LM Lyndem - Parasitology Research, 2012 - Springer
The efficacy of Cassia alata against cestode Hymenolepis diminuta was evaluated in our
study. Worms were maintained between rat model and beetle. Air-dried leaves of C. alata …

In vitro anthelmintic activities of Khaya anthotheca and Faidherbia albida extracts used in Chad by traditional healers for the treatment of helminthiasis and in silico …

B Christalin, M Besati… - Journal of Tropical …, 2024 - Wiley Online Library
Background. Helminthiasis is endemic in Chad and constitutes a public health problem,
particularly among school‐age children. The aim of this study was to evaluate the …

Effect of Lysimachia ramosa (Primulaceae) on helminth parasites: motility, mortality and scanning electron microscopic observations on surface topography

M Challam, B Roy, V Tandon - Veterinary Parasitology, 2010 - Elsevier
The alcoholic extract of Lysimachia ramosa Wall (Primulaceae) was tested in vitro against
helminth parasites, Fasciolopsis buski and Ascaris suum, from porcine hosts and Raillietina …

The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs

HR Vaca, AM Celentano, MA Toscanini… - PLoS Neglected …, 2021 - journals.plos.org
Background Echinococcosis and cysticercosis are neglected tropical diseases caused by
cestode parasites (family Taeniidae). Not only there is a small number of approved …

Chemical composition and broad-spectrum anthelmintic activity of a cultivar of toothache plant, Acmella oleracea, from Mizoram, India

PB Lalthanpuii, K Lalchhandama - Pharmaceutical Biology, 2020 - Taylor & Francis
Context A variety of Acmella oleracea (L.) RK Jansen (Asteraceae) is used by the Mizo
people of India and Myanmar for intestinal helminthiasis. Objective To perform a chemical …

Efficacy of China-made praziquantel for treatment of Schistosomiasis haematobium in Africa: A randomized controlled trial

XY Wang, J He, S Juma, F Kabole, J Guo… - PLoS Neglected …, 2019 - journals.plos.org
Background In the roadmap on the neglected tropical diseases (NTD) the World Health
Organization (WHO) aims at attaining at least 75% coverage of preventive chemotherapy in …

A novel pH-sensitive magnetic alginate–chitosan beads for albendazole delivery

FQ Wang, P Li, JP Zhang, AQ Wang… - Drug development and …, 2010 - Taylor & Francis
Background: Drug delivery system using polymer-coated magnetic carriers is considered as
an effective strategy for passive targeting, which can not only increase drug utilization but …