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Adeno-associated viral vectors in neuroscience research
Adeno-associated viral vectors (AAVs) are increasingly useful preclinical tools in
neuroscience research studies for interrogating cellular and neurocircuit functions and …
neuroscience research studies for interrogating cellular and neurocircuit functions and …
Nanowired bioelectric interfaces: focus review
Biological systems have evolved biochemical, electrical, mechanical, and genetic networks
to perform essential functions across various length and time scales. High-aspect-ratio …
to perform essential functions across various length and time scales. High-aspect-ratio …
[HTML][HTML] An open resource for non-human primate optogenetics
Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on
animal models more closely related to humans, such as non-human primates (NHPs), has …
animal models more closely related to humans, such as non-human primates (NHPs), has …
[HTML][HTML] The functional characterization of callosal connections
The brain operates through the synaptic interaction of distant neurons within flexible, often
heterogeneous, distributed systems. Histological studies have detailed the connections …
heterogeneous, distributed systems. Histological studies have detailed the connections …
Optimal anticipatory control as a theory of motor preparation: A thalamo-cortical circuit model
Across a range of motor and cognitive tasks, cortical activity can be accurately described by
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …
low-dimensional dynamics unfolding from specific initial conditions on every trial. These" …
Multimodal neural probes for combined optogenetics and electrophysiology
To understand how brain functions arise from interconnected neural networks, it is
necessary to develop tools that can allow simultaneous manipulation and recording of …
necessary to develop tools that can allow simultaneous manipulation and recording of …
[HTML][HTML] AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b−/− Grn−/− mice
Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …
Expression of the excitatory opsin ChRERα can be traced longitudinally in rat and nonhuman primate brains with PET imaging
Optogenetics is a widely used technology with potential for translational research. A critical
component of such applications is the ability to track the location of the transduced opsin in …
component of such applications is the ability to track the location of the transduced opsin in …
Using rAAV2-retro in rhesus macaques: promise and caveats for circuit manipulation
Background Recent genetic technologies such as opto-and chemogenetics allow for the
manipulation of brain circuits with unprecedented precision. Most studies employing these …
manipulation of brain circuits with unprecedented precision. Most studies employing these …
Micro-LED array-based photo-stimulation devices for optogenetics in rat and macaque monkey brains
Optogenetics is a powerful tool for controlling biological functions using light. Optical fibers
have been extensively utilized in optical stimulation devices for optogenetics. However, the …
have been extensively utilized in optical stimulation devices for optogenetics. However, the …