The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Safety Pharmacology is a rapidly develo** discipline that uses the basic principles of
pharmacology in a regulatory‐driven process to generate data to inform risk/benefit …

Hearts of anesthetized rats (n= 12 in each of 7 groups) were subjected to 5 min of regional
ischemia; on reperfusion, 100% exhibited ventricular tachycardia (VT), 83% ventricular …

OBJECTIVE: The objective was to evaluate the protective effect of ellagic acid against
experimentally induced cardiac arrhythmias, hypertrophy and its association with altered …

Twin studies have been largely responsible for showing the effects of genetic variance on a
quantitative trait. The model is based on the fact that monozygotic twins share all genes in …

Models for the study of arrhythmias in myocardial ischaemia and infarction: the use of the rat -
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Background The onset of acute myocardial infarction (MI) is accompanied by a rapid
increase in electrical instability and often fatal ventricular arrhythmias. The aim of this study …

Cardiac rhythm regulated by micro-macroscopic structures of heart. Pacemaker
abnormalities or disruptions in electrical conduction, lead to arrhythmic disorders may be …

The interest in mouse electrophysiology is expanding fast, despite the marked differences
between mouse and man. Different methods have become available to analyse the …

Studied were the effects of myocardial infarction (MI) on mild renal function loss in unilateral
nephrectomized (UnX) rats. UnX was performed, followed after 1 wk by a variable MI (UnX+ …