[HTML][HTML] Macrophages in health and disease

MD Park, A Silvin, F Ginhoux, M Merad - Cell, 2022‏ - cell.com
The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the task force for the …

K Zeppenfeld, J Tfelt-Hansen, M De Riva… - European heart …, 2022‏ - academic.oup.com
4004 ESC Guidelines label use of medication should be limited to situations where it is in
the patient's interest to do so, with regard to the quality, safety, and efficacy of care, and only …

Spatially resolved multiomics of human cardiac niches

K Kanemaru, J Cranley, D Muraro, AMA Miranda… - Nature, 2023‏ - nature.com
The function of a cell is defined by its intrinsic characteristics and its niche: the tissue
microenvironment in which it dwells. Here we combine single-cell and spatial …

Optogenetics for light control of biological systems

V Emiliani, E Entcheva, R Hedrich… - Nature Reviews …, 2022‏ - nature.com
Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Macrophages in cardiac remodelling after myocardial infarction

J Yap, J Irei, J Lozano-Gerona, S Vanapruks… - Nature reviews …, 2023‏ - nature.com
Myocardial infarction (MI), as a result of thrombosis or vascular occlusion, is the most
prevalent cause of morbidity and mortality among all cardiovascular diseases. The …

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

E Madissoon, AJ Oliver, V Kleshchevnikov… - Nature …, 2023‏ - nature.com
Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Targeting macrophages in cancer immunotherapy

Z Duan, Y Luo - Signal transduction and targeted therapy, 2021‏ - nature.com
Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

A network of macrophages supports mitochondrial homeostasis in the heart

JA Nicolás-Ávila, AV Lechuga-Vieco… - Cell, 2020‏ - cell.com
Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

[HTML][HTML] Spatial multi-omic map of human myocardial infarction

C Kuppe, RO Ramirez Flores, Z Li, S Hayat… - Nature, 2022‏ - nature.com
Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

[HTML][HTML] Determinants of resident tissue macrophage identity and function

C Blériot, S Chakarov, F Ginhoux - Immunity, 2020‏ - cell.com
Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …