From plants to wound dressing and transdermal delivery of bioactive compounds

GO Isopencu, CI Covaliu-Mierlă, IM Deleanu - Plants, 2023 - mdpi.com
Transdermal delivery devices and wound dressing materials are constantly improved and
upgraded with the aim of enhancing their beneficial effects, biocompatibility …

Novel approaches in food grade bigels properties and applications: A review

A Karimidastjerd, T Cetinkaya, M Tarahi, L Singh… - International Journal of …, 2024 - Elsevier
Food-grade bigels represent a highly innovative and versatile gel system within the food
industry, characterized by their unique ability to combine the advantages of both oleogels …

[HTML][HTML] 3D Printed Bigel: A Novel Delivery System for Cannabidiol-Rich Hemp Extract

A Gościniak, F Kocaj, A Stasiłowicz-Krzemień… - Gels, 2024 - mdpi.com
The therapeutic potential of Cannabis sativa L. extract has gained significant attention due to
its diverse medical applications. Sublingual administration remains a common delivery …

Bigel formulations of St. John's wort extract in wound healing: Toxicological aspects

Y Sotirova, D Vankova, O Tasinov… - Biotechnology & …, 2023 - Taylor & Francis
This study aimed to investigate the toxicological profile of hyperforin (HP) in silico and to
assess it in vivo after topical application of an HP-rich St. John's wort (SJW) extract. The …

[PDF][PDF] Phytochemical profiling and cardioprotective activity of Vernonia amygdalina ethanol extract (VAEE) against ISO-induced cardiotoxicity in rats

AT Prananda, A Dalimunthe, U Harahap… - …, 2023 - pharmacia.pensoft.net
Cardiovascular disorder is the leading cause death in the world, one of them are acute
myocardial infarction (AMI) which associated with hypertension and cardiac remodeling. ISO …

Characterization, Biocompatibility and Antioxidant Activity of Hydrogels Containing Propolis Extract as an Alternative Treatment in Wound Healing

LMMC Ferreira, YY Modesto, PDQ Souza… - Pharmaceuticals, 2024 - mdpi.com
Hydrogels consist of a network of highly porous polymeric chains with the potential for use
as a wound dressing. Propolis is a natural product with several biological properties …

Tissue Regeneration and Remodeling in Rat Models after Application of Hypericum perforatum L. Extract-Loaded Bigels

Y Sotirova, Y Kiselova-Kaneva, D Vankova, O Tasinov… - Gels, 2024 - mdpi.com
The wound-healing effect of St. John's Wort (SJW) is mainly attributed to hyperforin (HP), but
its low stability restricts its topical administration. This study investigates how “free” HP-rich …

[HTML][HTML] Innovative Epicardial Bigels Containing Amiodarone Hydrochloride: Pharmacotechnical and Analytical Characterization

C Pintea, RA Vlad, P Antonoaea, EM Rédai, M Bîrsan… - Pharmaceuticals, 2024 - mdpi.com
Background/Objectives: The search for novel ways of providing treatment also targets the
development of formulations used in drug delivery. Among the important characteristics of …

[PDF][PDF] In silico study of the toxicity of hyperforin and its metabolites

I Iliev, S Georgieva, Y Sotirova, V Andonova - Pharmacia, 2023 - pharmacia.pensoft.net
St. John's wort is a medicinal herb well-known for its antidepressant, anti-inflammatory,
antimycotic, and wound-healing properties. Hyperforin, the major phloroglucinol derivative …

In Situ Gelling Behavior and Biopharmaceutical Characterization of Nano-Silver-Loaded Poloxamer Matrices Designed for Nasal Drug Delivery

N Ivanova, N Ermenlieva, L Simeonova… - Gels, 2024 - mdpi.com
A combination of Poloxamer 407 (P407) and hydroxypropyl methylcellulose (HPMC)
hydrosols is proposed as an in situ thermo-gelling vehicle for the nasal drug delivery of …