Microglia-containing human brain organoids for the study of brain development and pathology

W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …

Microglia biology: one century of evolving concepts

M Prinz, S Jung, J Priller - Cell, 2019 - cell.com
Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …

[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes

ST Schafer, AAF Mansour, JCM Schlachetzki, M Pena… - Cell, 2023 - cell.com
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …

A microscale soft ionic power source modulates neuronal network activity

Y Zhang, J Riexinger, X Yang, E Mikhailova, Y **… - Nature, 2023 - nature.com
Bio-integrated devices need power sources to operate,. Despite widely used technologies
that can provide power to large-scale targets, such as wired energy supplies from batteries …

Mitochondrial complex I activity in microglia sustains neuroinflammation

L Peruzzotti-Jametti, CM Willis, G Krzak, R Hamel… - Nature, 2024 - nature.com
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …

Microglia in health and diseases: integrative hubs of the central nervous system (CNS)

A Sierra, VE Miron, RC Paolicelli… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …

Modeling Alzheimer's disease with iPSC-derived brain cells

J Penney, WT Ralvenius, LH Tsai - Molecular psychiatry, 2020 - nature.com
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …

Microglia and macrophages in brain homeostasis and disease

Q Li, BA Barres - Nature Reviews Immunology, 2018 - nature.com
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …

[HTML][HTML] Microglia: agents of the CNS pro-inflammatory response

JA Rodríguez-Gómez, E Kavanagh… - Cells, 2020 - mdpi.com
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases

E Nutma, N Fancy, M Weinert, S Tsartsalis… - Nature …, 2023 - nature.com
Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …