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Microglia-containing human brain organoids for the study of brain development and pathology
W Zhang, J Jiang, Z Xu, H Yan, B Tang, C Liu… - Molecular …, 2023 - nature.com
Microglia are resident immune cells in the central nervous system, playing critical roles in
brain development and homeostasis. Increasing evidence has implicated microglia …
brain development and homeostasis. Increasing evidence has implicated microglia …
Microglia biology: one century of evolving concepts
Microglia were first recognized as a distinct cell population in the CNS one century ago. For
a long time, they were primarily considered to be phagocytes responsible for removing …
a long time, they were primarily considered to be phagocytes responsible for removing …
[HTML][HTML] An in vivo neuroimmune organoid model to study human microglia phenotypes
Microglia are specialized brain-resident macrophages that play crucial roles in brain
development, homeostasis, and disease. However, until now, the ability to model …
development, homeostasis, and disease. However, until now, the ability to model …
A microscale soft ionic power source modulates neuronal network activity
Bio-integrated devices need power sources to operate,. Despite widely used technologies
that can provide power to large-scale targets, such as wired energy supplies from batteries …
that can provide power to large-scale targets, such as wired energy supplies from batteries …
Mitochondrial complex I activity in microglia sustains neuroinflammation
Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …
several chronic neurological diseases, including multiple sclerosis. Distinct metabolic and …
Microglia in health and diseases: integrative hubs of the central nervous system (CNS)
Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …
Modeling Alzheimer's disease with iPSC-derived brain cells
Alzheimer's disease is a devastating neurodegenerative disorder with no cure. Countless
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
promising therapeutics have shown efficacy in rodent Alzheimer's disease models yet failed …
Microglia and macrophages in brain homeostasis and disease
Q Li, BA Barres - Nature Reviews Immunology, 2018 - nature.com
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …
are increasingly recognized to be essential players in the development, homeostasis and …
[HTML][HTML] Microglia: agents of the CNS pro-inflammatory response
The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
pathogenesis of several neurodegenerative diseases. Though the research of microglia …
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases
Microglial activation plays central roles in neuroinflammatory and neurodegenerative
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …
diseases. Positron emission tomography (PET) targeting 18 kDa Translocator Protein …