Mechanisms of assembly and remodelling of the extracellular matrix
The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …
the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan …
A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
[HTML][HTML] Elastic fibers during aging and disease
Elastic fibers are essential constituents of the extracellular matrix of higher vertebrates and
endow several tissues and organs including lungs, skin and blood vessels with elasticity …
endow several tissues and organs including lungs, skin and blood vessels with elasticity …
TGF Beta− 1,− 2 and− 3 in the Modulation of Fibrosis in the Cornea and Other Organs
Abstract The TGF beta-1,-2 and-3 isoforms are transcribed from different genes but bind to
the same receptors and signal through the same canonical and non-canonical signal …
the same receptors and signal through the same canonical and non-canonical signal …
ADAMTS proteases in cardiovascular physiology and disease
The a disintegrin-like and metalloproteinase with thrombospondin motif (ADAMTS) family
comprises 19 proteases that regulate the structure and function of extracellular proteins in …
comprises 19 proteases that regulate the structure and function of extracellular proteins in …
Bioinspired supramolecular hydrogel from design to applications
Nature offers a wealth of opportunities to solve scientific and technological issues based on
its unique structures and function. The dynamic non‐covalent interaction is considered to be …
its unique structures and function. The dynamic non‐covalent interaction is considered to be …
Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis
L Mao, J Yang, J Yue, Y Chen, H Zhou, D Fan, Q Zhang… - Matrix Biology, 2021 - Elsevier
The tumor microenvironment encompasses a complex cellular network that includes cancer-
associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched …
associated fibroblasts, inflammatory cells, neo-vessels, and an extracellular matrix enriched …
Perlecan in pericellular mechanosensory cell-matrix communication, extracellular matrix stabilisation and mechanoregulation of load-bearing connective tissues
In this study, we review mechanoregulatory roles for perlecan in load-bearing connective
tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic …
tissues. Perlecan facilitates the co-acervation of tropoelastin and assembly of elastic …
Elastic fibre proteins in elastogenesis and wound healing
As essential components of our connective tissues, elastic fibres give tissues such as major
blood vessels, skin and the lungs their elasticity. Their formation is complex and co …
blood vessels, skin and the lungs their elasticity. Their formation is complex and co …
Fibrillin-1 regulates endothelial sprouting during angiogenesis
Fibrillin-1 is an extracellular matrix protein that assembles into microfibrils which provide
critical functions in large blood vessels and other tissues. Mutations in the fibrillin-1 gene are …
critical functions in large blood vessels and other tissues. Mutations in the fibrillin-1 gene are …