The search for novel anticancer agents with more selectivity and lower toxicity continues to
be an area of intensive investigation. The unique structural features of spirooxindoles …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

Multicomponent reactions (MCRs) are a valuable tool in diversity‐oriented synthesis. Its
application to privileged structures is gaining relevance in the fields of organic and …

DNA-encoded library technology (DELT) employs DNA as a barcode to track the sequence
of chemical reactions and enables the design and synthesis of libraries with billions of small …

Disubstituted oxindoles with a stereogenic quaternary carbon center exist widely in various
natural products and biologically active compounds. Various strategies have been …

Isatin is an important building block in organic synthesis. The electron‐deficient carbonyl in
C‐3 site is similar to aldehyde. C‐3 carbonyl is also able to function as the O‐nucleophile …

In the last years, numerous protocols have been published using ball milling for organic
synthesis. Compared to other methods such as microwave or ultrasound irradiation and …

Isatin has been used in design and synthesis of diverse types of heterocyclic and
carbocyclic compounds and considered as a valuable building block in organic synthesis …

Applying a multistep approach, novel indolin-2-ones (IND) that possess an arylidene motif
have been synthesized. Eight compounds were chosen for different biological tests …

A rapid and efficient ultrasound-promoted one-pot synthesis of spiro [indoline-3, 4′-pyrano
[2, 3-c] pyrazole] derivatives is described here. The reaction of substituted phenylhydrazine …