Targeting the TGFβ signalling pathway in disease
Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed,
some of which have reached Phase III clinical trials for a number of disease applications …
some of which have reached Phase III clinical trials for a number of disease applications …
Nicotine and the renin-angiotensin system
JM Oakes, RM Fuchs, JD Gardner… - American Journal …, 2018 - journals.physiology.org
Cigarette smoking is the single most important risk factor for the development of
cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in …
cardiovascular and pulmonary diseases (CVPD). Although cigarette smoking has been in …
Transforming growth factor-β in stem cells and tissue homeostasis
Abstract TGF-β 1–3 are unique multi-functional growth factors that are only expressed in
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
mammals, and mainly secreted and stored as a latent complex in the extracellular matrix …
Pathogenesis of chronic obstructive pulmonary disease
RM Tuder, I Petrache - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …
worldwide health care burden, approaching that imposed by transmittable infectious …
Mechanisms of airway remodeling
N Hirota, JG Martin - Chest, 2013 - Elsevier
Airway remodeling comprises the structural changes of airway walls, induced by repeated
injury and repair processes. It is characterized by the changes of tissue, cellular, and …
injury and repair processes. It is characterized by the changes of tissue, cellular, and …
Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies?
Changes in extracellular matrix (ECM) components in the lungs are associated with the
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
progression of respiratory diseases, such as asthma, chronic obstructive pulmonary disease …
PDE4 inhibition as a therapeutic strategy for improvement of pulmonary dysfunctions in Covid-19 and cigarette smoking
Abstract Angiotensin-converting enzyme 2 (ACE2) is the binding-site and entry-point for
SARS-CoV-2 in human and highly expressed in the lung. Cigarette smoking (CS) is the …
SARS-CoV-2 in human and highly expressed in the lung. Cigarette smoking (CS) is the …
Airway epithelium dysfunction in cystic fibrosis and COPD
Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene, whereas chronic
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …
obstructive pulmonary disease (COPD) is mainly caused by environmental factors (mostly …
The relationship between lung inflammation and cardiovascular disease
Acute and chronic lung inflammation is an underrecognized risk factor for cardiovascular
disease. Yet, there are compelling epidemiological data to indicate that airway exposures to …
disease. Yet, there are compelling epidemiological data to indicate that airway exposures to …
COPD as an endothelial disorder: endothelial injury linking lesions in the lungs and other organs?(2017 Grover Conference Series)
Chronic obstructive pulmonary disease (COPD) is characterized by chronic expiratory
airflow obstruction that is not fully reversible. COPD patients develop varying degrees of …
airflow obstruction that is not fully reversible. COPD patients develop varying degrees of …