Despite its intrinsic ability to regenerate form and function after injury, bone tissue can be
challenged by a multitude of pathological conditions. While innovative approaches have …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Bone fractures and segmental bone defects are a significant source of patient morbidity and
place a staggering economic burden on the healthcare system. The annual cost of treating …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Bone remodeling process relies on complex signaling pathway between osteoblasts and
osteoclasts and control mechanisms to achieve homeostasis of their growth and …

Conditions such as congenital anomalies, cancers, and trauma can all result in devastating
deficits of bone in the craniofacial skeleton. This can lead to significant alteration in function …

Congenital defects, trauma, and disease can compromise the integrity and functionality of
the skeletal system to the extent requiring implantation of bone grafts. Engineering of viable …

Bone substitutes can be designed to replicate physiological structure and function by
creating a microenvironment that supports crosstalk between bone and immune cells found …

Mesenchymal stem cells (MSCs) have gained increasing attention as a potential approach
for the treatment of bone injuries due to their multi-lineage differentiation potential and also …