Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …

Besides its important role in embryonic development and homeostatic self-renewal in adult
tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory …

The correct concentration of oxygen in all tissues is a hallmark of cellular wellness, and the
negative regulation of oxygen homeostasis is able to affect the cells and tissues of the whole …

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Hypoxia inducible factor (HIF) is the master oxygen sensor within cells and is central to the
regulation of cell responses to varying oxygen levels. HIF activation during hypoxia ensures …

Cells sense and respond to hypoxia through the activity of the transcription factor HIF
(hypoxia-inducible factor) and its regulatory hydroxylases, the prolyl hydroxylase domain …

Autism spectrum disorder (ASD) is a neurodevelopmental disease that is characterized by a
deficit in social interactions and communication, as well as repetitive and restrictive …

All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …

Hypoxia-inducible factors (HIFs) are stabilized during adverse inflammatory processes
associated with disorders such as inflammatory bowel disease, pathogen infection and …

Small-molecule stabilizers of hypoxia inducible factor (HIF) are being developed for the
treatment of renal anaemia. These molecules inhibit prolyl hydroxylase domain-containing …