[HTML][HTML] Effect of hesperidin on cardiovascular disease risk factors: The role of intestinal microbiota on hesperidin bioavailability

A Mas-Capdevila, J Teichenne, C Domenech-Coca… - Nutrients, 2020 - mdpi.com
Recently, hesperidin, a flavonone mainly present in citrus fruits, has emerged as a new
potential therapeutic agent able to modulate several cardiovascular diseases (CVDs) risk …

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases

A Roohbakhsh, H Parhiz, F Soltani, R Rezaee… - Life sciences, 2015 - Elsevier
Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species
that have various biological properties, particularly those for the prevention of cancer and …

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: an update

N Bhattacharjee, S Barma, N Konwar… - European journal of …, 2016 - Elsevier
Diabetic nephropathy (DN), a chronic complication of diabetes, is charecterized by
glomerular hypertrophy, proteinuria, decreased glomerular filtration, and renal fibrosis …

The role of protein kinase C in diabetic microvascular complications

D Pan, L Xu, M Guo - Frontiers in Endocrinology, 2022 - frontiersin.org
Protein kinase C (PKC) is a family of serine/threonine protein kinases, the activation of which
plays an important role in the development of diabetic microvascular complications. The …

[HTML][HTML] Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia and exploring the potential role in antioxidant and antihyperlipidemic in …

R Jayaraman, S Subramani, SHS Abdullah… - Biomedicine & …, 2018 - Elsevier
Abstracts Diabetes is the major health problem in modern civilization which occurs due to
inadequate metabolism of carbohydrate and lipid could cause tremendous changes in the …

Nutraceuticals for the treatment of diabetic retinopathy

MG Rossino, G Casini - Nutrients, 2019 - mdpi.com
Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus and
is characterized by degeneration of retinal neurons and neoangiogenesis, causing a severe …

Hesperetin protects against H2O2-triggered oxidative damage via upregulation of the Keap1-Nrf2/HO-1 signal pathway in ARPE-19 cells

C Zhu, Y Dong, H Liu, H Ren, Z Cui - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Age-related macular degeneration (AMD) is an irreversible vision loss disease that primarily
results from oxidative stress that causes oxidative damage to the retinal pigment epithelial …

A review of molecular mechanisms involved in anticancer and antiangiogenic effects of natural polyphenolic compounds

H Abbaszadeh, B Keikhaei… - Phytotherapy Research, 2019 - Wiley Online Library
The aim of this review is to obtain a further understanding of the reported inhibitory effects of
polyphenols on cancer cell proliferation and angiogenesis process and the probable …

[HTML][HTML] A comprehensive review on phytochemistry, bioactivities, toxicity studies, and clinical studies on Ficus carica Linn. leaves

Z Li, Y Yang, M Liu, C Zhang, J Shao, X Hou… - Biomedicine & …, 2021 - Elsevier
The leaves of Ficus carica Linn.(FC) have been widely used for medicine purposes since
ancient times, and its decoction is consumed as tea. Many scientific papers have been …

Hesperetin, a promising treatment option for diabetes and related complications: A literature review

H Yang, Y Wang, S Xu, J Ren, L Tang… - Journal of Agricultural …, 2022 - ACS Publications
The morbidity and mortality of diabetes have increased dramatically in recent decades.
Novel strategies for treating diabetes and its complications with minimal side effects are in …