The microbiome–gut–brain axis in Parkinson disease—from basic research to the clinic

AH Tan, SY Lim, AE Lang - Nature Reviews Neurology, 2022 - nature.com
Evidence for a close bidirectional link between the brain and the gut has led to a paradigm
shift in neurology, especially in the case of Parkinson disease (PD), in which gastrointestinal …

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

K Socała, U Doboszewska, A Szopa, A Serefko… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

Gastrointestinal involvement in Parkinson's disease: pathophysiology, diagnosis, and management

T Warnecke, KH Schäfer, I Claus, K Del Tredici… - npj Parkinson's …, 2022 - nature.com
Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

The gut–brain axis and its relation to Parkinson's disease: a review

EM Klann, U Dissanayake, A Gurrala… - Frontiers in aging …, 2022 - frontiersin.org
Parkinson's disease is a chronic neurodegenerative disease characterized by the
accumulation of misfolded alpha-synuclein protein (Lewy bodies) in dopaminergic neurons …

Gut microbiota: a novel therapeutic target for Parkinson's disease

M Zhu, X Liu, Y Ye, X Yan, Y Cheng, L Zhao… - Frontiers in …, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by motor dysfunction. Growing evidence has demonstrated that gut dysbiosis …

Gut liver brain axis in diseases: the implications for therapeutic interventions

M Yan, S Man, B Sun, L Ma, L Guo, L Huang… - Signal Transduction and …, 2023 - nature.com
Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Gut microbial ecosystem in Parkinson disease: new clinicobiological insights from multi‐omics

AH Tan, CW Chong, SY Lim, IKS Yap… - Annals of …, 2021 - Wiley Online Library
Objective Gut microbiome alterations in Parkinson disease (PD) have been reported
repeatedly, but their functional relevance remains unclear. Fecal metabolomics, which …

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - … and Targeted Therapy, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Mechanisms of peripheral levodopa resistance in Parkinson's disease

M Beckers, BR Bloem, MM Verbeek - npj Parkinson's Disease, 2022 - nature.com
Parkinson's disease (PD) is an increasingly common neurodegenerative condition. The
disease has a significant negative impact on quality of life, but a personalized management …

How diet and lifestyle can fine-tune gut microbiomes for healthy aging

M Tamayo, M Olivares, P Ruas-Madiedo… - Annual review of …, 2024 - annualreviews.org
Many physical, social, and psychological changes occur during aging that raise the risk of
develo** chronic diseases, frailty, and dependency. These changes adversely affect the …