Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …

Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-
coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety …

Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

In 1964, the psychoactive ingredient of Cannabis sativa, Δ 9-tetrahydrocannabinol (THC),
was isolated. Nearly 30 years later the endogenous counterparts of THC, collectively termed …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The most frequent cause of portal hypertension is liver cirrhosis, and many of lethal
complications of cirrhosis such as ascites and gastroesophageal variceal hemorrhage are …

The endocannabinoids are a family of lipid messengers that engage the cell surface
receptors that are targeted by Δ9-tetrahydrocannabinol, the active principle in marijuana …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

The term'endocannabinoid'—originally coined in the mid-1990s after the discovery of
membrane receptors for the psychoactive principle in Cannabis, Δ9-tetrahydrocannabinol …