Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …

Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …

The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …

Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids
control important cellular processes, including cell proliferation, apoptosis, metabolism and …

Ischaemic heart disease and the heart failure that often results, remain the leading causes of
death and disability in Europe and worldwide. As such, in order to prevent heart failure and …

Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For
patients presenting with an acute ST-segment elevation myocardial infarction (STEMI) …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

The strategy of 'drugging the cancer kinome'has led to the successful development and
regulatory approval of several novel molecular targeted agents. The spotlight is now shifting …

Phosphoinositide 3-kinases (PI3K) orchestrate cell responses including mitogenic signaling,
cell survival and growth, metabolic control, vesicular trafficking, degranulation, cytoskeletal …