Personalized therapy for mycophenolate: consensus report by the international association of therapeutic drug monitoring and clinical toxicology
S Bergan, M Brunet, DA Hesselink… - Therapeutic drug …, 2021 - journals.lww.com
When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy,
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …
fixed doses were recommended by the manufacturer. Awareness of the potential for a more …
Pharmacogenomics in the clinic
After decades of discovery, inherited variations have been identified in approximately 20
genes that affect about 80 medications and are actionable in the clinic. And some …
genes that affect about 80 medications and are actionable in the clinic. And some …
An evidence‐based framework for evaluating pharmacogenomics knowledge for personalized medicine
Clinical annotations are one of the most popular resources available on the
Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the …
Pharmacogenomics Knowledgebase (PharmGKB). Each clinical annotation summarizes the …
The “All of Us” research program
All of Us Research Program … - New England Journal of …, 2019 - Mass Medical Soc
Knowledge gained from observational cohort studies has dramatically advanced the
prevention and treatment of diseases. Many of these cohorts, however, are small, lack …
prevention and treatment of diseases. Many of these cohorts, however, are small, lack …
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing: 2017 update
U Amstutz, LM Henricks, SM Offer… - Clinical …, 2018 - Wiley Online Library
The purpose of this guideline is to provide information for the interpretation of clinical
dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to …
dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to …
Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for pharmacogenetics‐guided warfarin dosing: 2017 update
This document is an update to the 2011 Clinical Pharmacogenetics Implementation
Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing …
Consortium (CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing …
[LIVRE][B] The American Psychiatric Association practice guideline for the treatment of patients with schizophrenia
American Psychiatric Association - 2020 - books.google.com
The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …
Schizophrenia seeks to reduce these substantial psychosocial and public health …
Prediction of CYP2D6 phenotype from genotype across world populations
Purpose: Owing to its highly polymorphic nature and major contribution to the metabolism
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
Variant interpretation: functional assays to the rescue
Classical genetic approaches for interpreting variants, such as case-control or co-
segregation studies, require finding many individuals with each variant. Because the …
segregation studies, require finding many individuals with each variant. Because the …
PharmVar GeneFocus: CYP2D6
C Nofziger, AJ Turner, K Sangkuhl… - Clinical …, 2020 - Wiley Online Library
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …