In animals, systemic control of metabolism is conducted by metabolic tissues and relies on
the regulated circulation of a plethora of molecules, such as hormones and lipoprotein …

MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …

MicroRNAs (miRNAs) are endogenous non-coding small RNA molecules that can be
secreted into the circulation and exist in remarkably stable forms. Like intercellular miRNAs …

Alcoholism is a widespread and damaging behaviour of people throughout the world. Long-
term alcohol consumption has resulted in alcoholic liver disease (ALD) being the leading …

Abstract Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1. 14) is the first and rate-limiting
enzyme in the classic bile acid synthesis pathway. Much progress has been made in …

This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

NAFLD affects a large proportion of the US population and its incidence and prevalence are
increasing to epidemic proportions around the world. As with other liver diseases that cause …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

Discovered in 1993, micoRNAs (miRNAs) are now recognized as one of the major
regulatory gene families in eukaryotes. To date, 24521 microRNAs have been discovered …