Preeclampsia beyond pregnancy: long-term consequences for mother and child

HR Turbeville, JM Sasser - American Journal of Physiology …, 2020 - journals.physiology.org
Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

[HTML][HTML] Preeclampsia: linking placental ischemia with maternal endothelial and vascular dysfunction

BA Bakrania, FT Spradley, HA Drummond… - Comprehensive …, 2020 - ncbi.nlm.nih.gov
Preeclampsia (PE), a hypertensive disorder, occurs in 3% to 8% of pregnancies in the
United States and affects over 200,000 women and newborns per year. The United States …

Animal models of preeclampsia: causes, consequences, and interventions

KL Gatford, PH Andraweera, CT Roberts, AS Care - Hypertension, 2020 - Am Heart Assoc
Preeclampsia is a common pregnancy complication, affecting 2% to 8% of pregnancies
worldwide, and is an important cause of both maternal and fetal morbidity and mortality …

Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia

SD Burke, ZK Zsengellér, EV Khankin… - The Journal of …, 2016 - Am Soc Clin Investig
Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound
sensitivity to vasopressors, such as angiotensin II, and is associated with substantial …

Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure

ND Paauw, F Terstappen, W Ganzevoort, JA Joles… - …, 2017 - Am Heart Assoc
Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …

Maternal vascular physiology in preeclampsia

S Goulopoulou - Hypertension, 2017 - Am Heart Assoc
Goulopoulou Vascular Changes in Preeclampsia 1067 are increased in placental and
vascular tissues from women with preeclampsia. Systemic pharmacological inhibition of …

The endothelin system: a critical player in the pathophysiology of preeclampsia

JP Granger, FT Spradley, BA Bakrania - Current hypertension reports, 2018 - Springer
Abstract Purpose of Review Preeclampsia (PE) is a disorder of pregnancy typically
characterized by new-onset hypertension and proteinuria after gestational week 20 …

Animal models of preeclampsia: investigating pathophysiology and therapeutic targets

BA Bakrania, EM George, JP Granger - American journal of obstetrics and …, 2022 - Elsevier
Animal models have been critical in investigating the pathogenesis, mediators, and even
therapeutic options for a number of diseases, including preeclampsia. Preeclampsia is the …

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

JA Ishimwe - Physiological reports, 2021 - Wiley Online Library
Preeclampsia is a devastating hypertensive pregnancy disorder that currently affects 2%–
8% of pregnancies worldwide. It is associated with maternal and fetal mortality and morbidity …

The enigma of continual plasma volume expansion in pregnancy: critical role of the renin-angiotensin-aldosterone system

CA West, JM Sasser, C Baylis - American Journal of …, 2016 - journals.physiology.org
Pregnancy is characterized by avid renal sodium retention and plasma volume expansion in
the presence of decreased blood pressure. Decreased maternal blood pressure is a …