[HTML][HTML] Diabetes mellitus—Progress and opportunities in the evolving epidemic

ED Abel, AL Gloyn, C Evans-Molina, JJ Joseph… - Cell, 2024 - cell.com
Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

Feeding gut microbes to nourish the brain: unravelling the diet–microbiota–gut–brain axis

E Schneider, KJ O'Riordan, G Clarke, JF Cryan - Nature metabolism, 2024 - nature.com
The prevalence of brain disorders, including stress-related neuropsychiatric disorders and
conditions with cognitive dysfunction, is rising. Poor dietary habits contribute substantially to …

On the pathogenesis of obesity: Causal models and missing pieces of the puzzle

F Magkos, TIA Sørensen, D Raubenheimer… - Nature …, 2024 - nature.com
Application of the physical laws of energy and mass conservation at the whole-body level is
not necessarily informative about causal mechanisms of weight gain and the development of …

The gut-brain axis mediates bacterial driven modulation of reward signaling

JS Kim, KC Williams, RA Kirkland, R Schade… - Molecular …, 2023 - Elsevier
Objective Our goal is to investigate if microbiota composition modulates reward signaling
and assess the role of the vagus in mediating microbiota to brain communication. Methods …

Dietary polyphenols regulate appetite mechanism via gut-brain axis and gut homeostasis

H Liu, X Guo, K Jiang, B Shi, L Liu, R Hou, G Chen… - Food Chemistry, 2024 - Elsevier
Nowadays, due to the rise of fast-food consumption, the metabolic diseases are increasing
as a result of high-sugar and high-fat diets. Therefore, there is an urgent need for natural …

[HTML][HTML] The vagus nerve: An old but new player in brain–body communication

L Ma, HB Wang, K Hashimoto - Brain, Behavior, and Immunity, 2024 - Elsevier
The vagus nerve is a crucial component of the parasympathetic nervous system, facilitating
communication between the brain and various organs including the ears, heart, lungs …

AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference

NT Nyema, AD McKnight, AG Vargas-Elvira… - Molecular …, 2023 - Elsevier
Objective The learned associations between sensory cues (eg, taste, smell) and nutritive
value (eg, calories, post-ingestive signaling) of foods powerfully influences our eating …

[HTML][HTML] Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake

CM Lorch, NW Hayes, JL **a, SW Fleps, HE McMorrow… - Cell reports, 2024 - cell.com
Rapid gut-brain communication is critical to maintain energy balance and is disrupted in diet-
induced obesity. In particular, the role of carbohydrate overconsumption in the regulation of …

Hepatic vagal afferents convey clock-dependent signals to regulate circadian food intake

LN Woodie, LC Melink, M Midha, AM de Araújo… - Science, 2024 - science.org
Circadian desynchrony induced by shiftwork or jet lag is detrimental to metabolic health, but
how synchronous or desynchronous signals are transmitted among tissues is unknown. We …

[HTML][HTML] Molecular Pharmacology of Vitamin C and Relevance to Health and Obesity—A Narrative Review

RB Wilson, Y Liang, D Kaushal, A Carr - International journal of molecular …, 2024 - mdpi.com
The role of food constituents as pharmacological agents is an important consideration in
health and obesity. Vitamin C acts as a small molecule antioxidant but is also a co-factor for …