Erdheim-Chester disease (ECD) is a rare histiocytosis that was recently recognized as a
neoplastic disorder owing to the discovery of recurrent activating MAPK (RAS-RAF-MEK …

The historic term 'histiocytosis' meaning 'tissue cell'is used as a unifying concept for
diseases characterized by pathogenic myeloid cells that share histological features with …

ALK-positive histiocytosis is a rare subtype of histiocytic neoplasm first described in 2008 in
3 infants with multisystemic disease involving the liver and hematopoietic system. This entity …

IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ
system. Common presentations include major salivary and lacrimal gland enlargement …

Erdheim–Chester disease is a rare, non-Langerhans cell histiocytosis histologically
characterized by multi-systemic proliferation of mature histiocytes in a background of …

Histiocytic neoplasms, a rare and heterogeneous group of disorders, primarily include
Erdheim-Chester disease, Langerhans cell histiocytosis, and Rosai-Dorfman disease. Due …

Erdheim-Chester disease (ECD) is a rare, multisystemic, inflammatory, non–Langerhans cell
histiocytic neoplasm. The discovery of recurrent and somatic mutations in the mitogen …

Erdheim-Chester disease (ECD) is characterized by the infiltration of tissues by foamy
CD68+ CD1a− histiocytes, with 1500 known cases since 1930. Mutations activating the …

Histiocytic neoplasms are rare hematologic disorders accounting for less than 1% of cancers
of the soft tissue and lymph nodes. Clinical presentation and prognosis of these disorders …

Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation
of CD68 (+) cells with various admixed inflammatory infiltrates. The identification of the …