Next-generation stem cells—ushering in a new era of cell-based therapies

EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Emerging modalities and implantable technologies for neuromodulation

SM Won, E Song, JT Reeder, JA Rogers - Cell, 2020 - cell.com
Techniques for neuromodulation serve as effective routes to care of patients with many types
of challenging conditions. Continued progress in this field of medicine will require (1) …

Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

D Chen, Q Lou, XJ Song, F Kang, A Liu… - Nature …, 2024 - nature.com
Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …

Molecular basis for selective activation of DREADD-based chemogenetics

S Zhang, RH Gumpper, XP Huang, Y Liu, BE Krumm… - Nature, 2022 - nature.com
Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …

Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice

MH Yi, YU Liu, K Liu, T Chen, DB Bosco… - Brain, behavior, and …, 2021 - Elsevier
Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …

[HTML][HTML] Context-specific striatal astrocyte molecular responses are phenotypically exploitable

X Yu, J Nagai, M Marti-Solano, JS Soto, G Coppola… - Neuron, 2020 - cell.com
Astrocytes tile the central nervous system and are widely implicated in brain diseases, but
the molecular mechanisms by which astrocytes contribute to brain disorders remain …

A review on computer‐aided chemogenomics and drug repositioning for rational COVID‐19 drug discovery

S Maghsoudi, B Taghavi Shahraki… - Chemical biology & …, 2022 - Wiley Online Library
Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …

Optogenetic and chemogenetic therapies for epilepsy

MC Walker, DM Kullmann - Neuropharmacology, 2020 - Elsevier
Drug-resistant epilepsy remains a significant health-care burden. The most effective
treatment is surgery, but this is suitable for very few patients because of the unacceptable …

Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity

JA Balouek, CA Mclain, AR Minerva… - Journal of …, 2023 - jneurosci.org
Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety,
suicide, and other psychiatric disorders, particularly after facing additional stressful events …

Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience

J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …