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Next-generation stem cells—ushering in a new era of cell-based therapies
EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …
decades. This has primarily involved the transplantation of primary cells such as …
Emerging modalities and implantable technologies for neuromodulation
Techniques for neuromodulation serve as effective routes to care of patients with many types
of challenging conditions. Continued progress in this field of medicine will require (1) …
of challenging conditions. Continued progress in this field of medicine will require (1) …
Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice
D Chen, Q Lou, XJ Song, F Kang, A Liu… - Nature …, 2024 - nature.com
Anxiety-associated symptoms following acute stress usually become extinct gradually within
a period of time. However, the mechanisms underlying how individuals cope with stress to …
a period of time. However, the mechanisms underlying how individuals cope with stress to …
Molecular basis for selective activation of DREADD-based chemogenetics
Designer receptors exclusively activated by designer drugs (DREADDs) represent a
powerful chemogenetic technology for the remote control of neuronal activity and cellular …
powerful chemogenetic technology for the remote control of neuronal activity and cellular …
Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice
Microglia play an important role in the central sensitization and chronic pain. However, a
direct connection between microglial function and pain development in vivo remains …
direct connection between microglial function and pain development in vivo remains …
[HTML][HTML] Context-specific striatal astrocyte molecular responses are phenotypically exploitable
Astrocytes tile the central nervous system and are widely implicated in brain diseases, but
the molecular mechanisms by which astrocytes contribute to brain disorders remain …
the molecular mechanisms by which astrocytes contribute to brain disorders remain …
A review on computer‐aided chemogenomics and drug repositioning for rational COVID‐19 drug discovery
Application of materials capable of energy harvesting to increase the efficiency and
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
environmental adaptability is sometimes reflected in the ability of discovery of some traces in …
Optogenetic and chemogenetic therapies for epilepsy
Drug-resistant epilepsy remains a significant health-care burden. The most effective
treatment is surgery, but this is suitable for very few patients because of the unacceptable …
treatment is surgery, but this is suitable for very few patients because of the unacceptable …
Reactivation of early-life stress-sensitive neuronal ensembles contributes to lifelong stress hypersensitivity
Early-life stress (ELS) is one of the strongest lifetime risk factors for depression, anxiety,
suicide, and other psychiatric disorders, particularly after facing additional stressful events …
suicide, and other psychiatric disorders, particularly after facing additional stressful events …
Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience
J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …