Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Male fertility throughout life hinges on the successful production of motile sperm, a
developmental process that involves three coordinated transitions: mitosis, meiosis, and …

Reprogramming of H3K9me3-dependent heterochromatin is required for early development.
How H3K9me3 is involved in early human development remains, however, largely unclear …

Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition.
However, the global view of ZGA, particularly at initiation, is incompletely understood. Here …

Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote,
which gives rise to an embryo. How parental epigenetic memories are inherited and …

The spermatozoon is a highly differentiated and polarized cell, with two main structures: the
head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum …

The smooth and precise transition from totipotency to pluripotency is a key process in
embryonic development, generating pluripotent stem cells capable of forming all cell types …

MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the
molecular and genetic events triggering MYC amplification and malignant transformation …

Conventional dogma presumes that protamine-mediated DNA compaction in sperm is
achieved by electrostatic interactions between DNA and the arginine-rich core of …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …