Abstract Alzheimer's disease (AD), the most common cause of adult-onset dementia is
characterized by a progressive decline of cognitive functions accompanied by behavioral …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …

Currently, acetylcholinesterase (AChE) inhibitors are the most promising class of drugs for
the treatment of Alzheimer's disease (AD). Galantamine is a reversible, competitive, tertiary …

Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a
potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Compared …

Background: Cholinesterase inhibitors (ChEIs) are the only drugs marketed for the treatment
of Alzheimer's disease. Despite numerous randomized controlled trials, the efficacy and …

Ethnopharmacological relevance Alzheimer's disease (AD), a deleterious
neurodegenerative disorder that impairs memory, cognitive functions and may lead to …

Publisher Summary This chapter discusses the chemical and biological aspects of
Narcissus alkaloids. Numerous alkaloids have been isolated from Narcissus …

Cholinesterase inhibitors are the 'first-line'agents in the treatment of Alzheimer's disease.
This article presents the latest information on their pharmacokinetic properties and …

Background: Parallel with the development of hypotheses regarding cholinergic involvement
in geriatric memory dysfunction, the first attempts to treat patients with Alzheimer's disease …