Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

One strategy employed by bacterial strains to resist β-lactam antibiotics is the expression of
metallo-β-lactamases requiring Zn2+ for activity. In the last few years, many new zinc β …

Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

Flavodiiron proteins (FDPs, also called flavoproteins, Flvs) are modular enzymes widely
present in Bacteria and Archaea. The evolution of cyanobacteria and oxygenic …

High-spin non-heme iron–nitrosyls are of direct interest to both the chemical and biological
communities as these species exhibit interesting chemical properties and act as direct …

Flavodiiron proteins possess reductive scavenging properties toward dioxygen and/or nitric
oxide in various microorganisms. Among them, the Desulfovibrio gigas flavodiiron protein …

Highlights•The geological and biological records suggest that O 2 was not available and
biologically meaningful until relatively late in Earth history.•Early life evolved in an anoxic …

The metallobiochemistry underlying the formation of the inorganic N–N-bond-containing
molecules nitrous oxide (N2O), dinitrogen (N2), and hydrazine (N2H4) is essential to the …

Synechocystis sp PCC 6803 has four genes encoding flavodiiron proteins (FDPs; Flv1 to
Flv4). Here, we investigated the flv4-flv2 operon encoding the Flv4, Sll0218, and Flv2 …