Antibodies to combat viral infections: development strategies and progress

G Pantaleo, B Correia, C Fenwick, VS Joo… - Nature Reviews Drug …, 2022 - nature.com
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …

Glycoconjugates: synthesis, functional studies, and therapeutic developments

SS Shivatare, VS Shivatare, CH Wong - Chemical reviews, 2022 - ACS Publications
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

I Kimura, Y Kosugi, J Wu, J Zahradnik, D Yamasoba… - Cell reports, 2022 - cell.com
Summary SARS-CoV-2 Lambda, a variant of interest, has spread in some South American
countries; however, its virological features and evolutionary traits remain unclear. In this …

Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models

HY Huang, HY Liao, X Chen, SW Wang… - Science Translational …, 2022 - science.org
A major challenge to end the pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …

Advances in the development of influenza virus vaccines

F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …

Biological roles of glycans

A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

JFW Chan, KKW To, H Tse, DY **, KY Yuen - Trends in microbiology, 2013 - cell.com
As exemplified by coronaviruses and influenza viruses, bats and birds are natural reservoirs
for providing viral genes during evolution of new virus species and viruses for interspecies …

Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor

P Zhao, JL Praissman, OC Grant, Y Cai, T **ao… - Cell host & …, 2020 - cell.com
The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind
to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and …

Influenza A viruses: new research developments

RA Medina, A García-Sastre - Nature Reviews Microbiology, 2011 - nature.com
Influenza A viruses are zoonotic pathogens that continuously circulate and change in
several animal hosts, including birds, pigs, horses and humans. The emergence of novel …

Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells

YC Liu, HY Yen, CY Chen, CH Chen, PF Cheng… - Proceedings of the …, 2011 - pnas.org
Protein glycosylation is an important posttranslational process, which regulates protein
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …