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Antibodies to combat viral infections: development strategies and progress
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance
Summary SARS-CoV-2 Lambda, a variant of interest, has spread in some South American
countries; however, its virological features and evolutionary traits remain unclear. In this …
countries; however, its virological features and evolutionary traits remain unclear. In this …
Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models
HY Huang, HY Liao, X Chen, SW Wang… - Science Translational …, 2022 - science.org
A major challenge to end the pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …
coronavirus 2 (SARS-CoV-2) is to develop a broadly protective vaccine that elicits long-term …
Advances in the development of influenza virus vaccines
F Krammer, P Palese - Nature reviews Drug discovery, 2015 - nature.com
Influenza virus infections are a major public health concern and cause significant morbidity
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
and mortality worldwide. Current influenza virus vaccines are an effective countermeasure …
Biological roles of glycans
A Varki - Glycobiology, 2017 - academic.oup.com
Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …
Interspecies transmission and emergence of novel viruses: lessons from bats and birds
JFW Chan, KKW To, H Tse, DY **, KY Yuen - Trends in microbiology, 2013 - cell.com
As exemplified by coronaviruses and influenza viruses, bats and birds are natural reservoirs
for providing viral genes during evolution of new virus species and viruses for interspecies …
for providing viral genes during evolution of new virus species and viruses for interspecies …
Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor
The SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind
to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and …
to the cell surface receptor angiotensin converting enzyme 2 (ACE2) glycoprotein and …
Influenza A viruses: new research developments
Influenza A viruses are zoonotic pathogens that continuously circulate and change in
several animal hosts, including birds, pigs, horses and humans. The emergence of novel …
several animal hosts, including birds, pigs, horses and humans. The emergence of novel …
Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells
YC Liu, HY Yen, CY Chen, CH Chen, PF Cheng… - Proceedings of the …, 2011 - pnas.org
Protein glycosylation is an important posttranslational process, which regulates protein
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …
folding and functional expression. Studies have shown that abnormal glycosylation in tumor …