The research of mobile robot path planning has shifted from the static environment to the
dynamic environment, from the two-dimensional environment to the high-dimensional …

Despite the widespread importance of RING/U-box E3 ubiquitin ligases in ubiquitin (Ub)
signaling, the mechanism by which this class of enzymes facilitates Ub transfer remains …

Allosteric regulation is used as a very efficient mechanism to control protein activity in most
biological processes, including signal transduction, metabolism, catalysis and gene …

It is now well accepted that structures alone cannot explain protein function and biochemical
data. Indeed, dynamics on different timescales play an important role in their function. Many …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

Understanding the driving forces underlying molecular recognition is of fundamental
importance in chemistry and biology. The challenge is to unravel the binding …

Rational drug design is predicated on knowledge of the three-dimensional structure of the
protein− ligand complex and the thermodynamics of ligand binding. Despite the …

Finding the dynamics of an entire macromolecule is a complex problem as the model-free
parameter values are intricately linked to the Brownian rotational diffusion of the molecule …

A plethora of modified nucleotides extends the chemical and conformational space for
natural occurring RNAs. tRNAs constitute the class of RNAs with the highest modification …

Inside cells, the concentration of macromolecules can reach up to 400 g/L. In such crowded
environments, proteins are expected to behave differently than in vitro. It has been shown …