Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene
therapy owing to its minimal pathogenicity and ability to establish long-term gene expression …

Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

The innate immune response is critical for recognizing and controlling infections through the
release of cytokines and chemokines. However, severe pathology during some infections …

The pathogenesis of COVID-19 is associated with a hyperinflammatory response; however,
the precise mechanism of SARS-CoV-2-induced inflammation is poorly understood. Here …

An effective tumor vaccine vector that can rapidly display neoantigens is urgently needed.
Outer membrane vesicles (OMVs) can strongly activate the innate immune system and are …

Until recently, the development of new human adjuvants was held back by a poor
understanding of their mechanisms of action. The field was revolutionized by the discovery …

The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …

Lactobacilli comprise an important group of probiotics for both human and animals. The
emerging concern regarding safety problems associated with live microbial cells is …

Simple Summary Nephrotoxicity is the dose-limiting factor of cisplatin treatment.
Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible …

Some people remain healthier throughout life than others but the underlying reasons are
poorly understood. Here we hypothesize this advantage is attributable in part to optimal …