High blood pressure is responsible for the modulation of blood vessel morphology and
function. Arterial hypertension is considered to play a significant role in atherosclerotic …

Background Valvular incompetence and reflux are common features of primary varicose
veins, and have long been thought to be their cause. Recent evidence, however, suggests …

AIM: The aim of this article was first to review the complex pathophysiological mechanisms
responsible for symptoms and signs of primary chronic venous disease (CVD) that allow the …

Background: Open Access Editor's Choice Review Migraine: Advances in the Pathogenesis
and Treatment by Horia Pleș 1, Ioan-Alexandru Florian 2,*, Teodora-Larisa Timis 3 …

Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …

Matrix metalloproteinases (MMPs) were originally identified as matrixin proteases that act in
the extracellular matrix. Recent works have uncovered nontraditional roles for MMPs in the …

Objective The focus of this review is to review potential diagnostic and therapeutic
biomarkers associated with migraine. Background Migraine headache is a common disease …

Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound
zinc-dependent endopeptidases that have the combined capacity to degrade all the …

Chronic Kidney Disease (CKD) represents a risk factor for fatal and nonfatal cardiovascular
(CV) events, including peripheral vascular disease (PVD). This occurs because CKD …

Chronic kidney disease (CKD) is currently defined as the presence of proteinuria and/or an
eGFR< 60 mL/min/1.73 m2 on the basis of the renal diagnosis. The global dimension of …