Physiological‐based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20‐years; in‐depth analysis of applications, organizations …
E El‐Khateeb, S Burkhill, S Murby… - … & Drug Disposition, 2021 - Wiley Online Library
We assess the advancement of physiologically based pharmacokinetic (PBPK) modeling
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
and simulation (M&S) over the last 20 years (start of 2000 to end of 2019) focusing on the …
Theophylline: Old drug in a new light, application in COVID-19 through computational studies
Theophylline (3-methyxanthine) is a historically prominent drug used to treat respiratory
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …
diseases, alone or in combination with other drugs. The rapid onset of the COVID-19 …
Applied concepts in PBPK modeling: how to build a PBPK/PD model
L Kuepfer, C Niederalt, T Wendl… - CPT …, 2016 - Wiley Online Library
The aim of this tutorial is to introduce the fundamental concepts of physiologically based
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …
pharmacokinetic/pharmacodynamic (PBPK/PD) modeling with a special focus on their …
Development and evaluation of a generic physiologically based pharmacokinetic model for children
Background Clinical trials in children are being encouraged by regulatory authorities in light
of the immense off-label and unlicensed use of drugs in the paediatric population. The use …
of the immense off-label and unlicensed use of drugs in the paediatric population. The use …
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular …
Today, in silico studies and trial simulations already complement experimental approaches
in pharmaceutical R&D and have become indispensable tools for decision making and …
in pharmaceutical R&D and have become indispensable tools for decision making and …
Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
In clinical development stages, an a priori assessment of the sensitivity of the
pharmacokinetic behavior with respect to physiological and anthropometric properties of …
pharmacokinetic behavior with respect to physiological and anthropometric properties of …
Informatics and data analytics to support exposome-based discovery for public health
The complexity of the human exposome—the totality of environmental exposures
encountered from birth to death—motivates systematic, high-throughput approaches to …
encountered from birth to death—motivates systematic, high-throughput approaches to …
Development of a whole-body physiologically based pharmacokinetic approach to assess the pharmacokinetics of drugs in elderly individuals
Background Because of the vulnerability and frailty of elderly adults, clinical drug
development has traditionally been biased towards young and middle-aged adults. Recent …
development has traditionally been biased towards young and middle-aged adults. Recent …
Mechanistic approaches to predicting oral drug absorption
Modeling and simulation of oral drug absorption have been widely used in drug discovery,
development, and regulation. Predictive absorption models are used to determine the rate …
development, and regulation. Predictive absorption models are used to determine the rate …
Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development
F Khalil, S Läer - BioMed Research International, 2011 - Wiley Online Library
The concept of physiologically based pharmacokinetic (PBPK) modeling was introduced
years ago, but it has not been practiced significantly. However, interest in and …
years ago, but it has not been practiced significantly. However, interest in and …