Cyclic peptides as a therapeutic modality are attracting a lot of attention due to their potential
for oral absorption and accessibility to intracellular tough targets. Here, starting with a drug …

Recently, the world has witnessed outbreak of a novel Coronavirus (SARS-CoV-2), the virus
which initially emerged in Wuhan, China has now made its way to a large part of the world …

The serum level of iron in humans is tightly controlled by the action of the hormone hepcidin
on the iron efflux transporter ferroportin. Hepcidin regulates iron absorption and recycling by …

Hedgehog signalling is fundamental to embryonic development and postnatal tissue
regeneration. Aberrant postnatal Hedgehog signalling leads to several malignancies …

The SARS-CoV-2 was confirmed to cause the global pandemic of coronavirus disease 2019
(COVID-19). The 3-chymotrypsin-like protease (3CLpro), an essential enzyme for viral …

Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA
and evade host immune defense systems. Previous structures of Nsp15 from across …

G protein-coupled receptors (GPCRs) are critical drug targets. GPCRs convey signals from
the extracellular to the intracellular environment through G proteins. Some ligands that bind …

Targeted covalent inhibitor design is gaining increasing interest and acceptance. A typical
covalent kinase inhibitor design targets a reactive cysteine; however, this strategy is limited …

The thrombin binding aptamer (TBA) is a prototypical platform used to understand the impact
of chemically-modified nucleotides on aptamer stability and target affinity. To provide …

The SARS coronavirus 2 (SARS-CoV-2) main protease (Mpro) is an attractive broad-
spectrum antiviral drug target. Despite the enormous progress in structure elucidation, the …