Nanomaterials have attractive physicochemical properties. A variety of nanomaterials such
as inorganic, lipid, polymers, and protein nanoparticles have been widely developed for …

The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from
satisfactory due to some issues such as tumor heterogeneity and resistance to …

Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the most widely
used cancer chemotherapeutics. Although cisplatin and carboplatin are used primarily in …

Chirality and molecular conformation are central components of life: biological systems rely
on stereospecific interactions between discrete (macro) molecular conformers, and the …

Metal-free magnetic resonance imaging (MRI) agents could overcome the established
toxicity associated with metal-based agents in some patient populations and enable new …

This paper describes the synthesis of a polymer–prodrug conjugate, its aqueous self-
assembly, noncovalent encapsulation of a second drug, and stimuli-responsive intracellular …

The grafting-through copolymerization of two distinct macromonomers via ring-opening
metathesis polymerization is typically used to form statistical or diblock bottlebrush polymers …

Nitroxides occupy a privileged position among plausible metal-free magnetic resonance
imaging (MRI) contrast agents (CAs) due to their inherently low-toxicity profiles; …

Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based
chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its …

Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and
have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic …