Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of …
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
International IBD Genetics Consortium (IIBDGC)… - Nature …, 2013 - nature.com
Using the ImmunoChip custom genoty** array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …
Genetic variability in the regulation of gene expression in ten regions of the human brain
Germ-line genetic control of gene expression occurs via expression quantitative trait loci
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …
(eQTLs). We present a large, exon-specific eQTL data set covering ten human brain regions …
Genome-wide associations of human gut microbiome variation and implications for causal inference analyses
Abstract Recent population-based,,–and clinical studies have identified a range of factors
associated with human gut microbiome variation. Murine quantitative trait loci, human twin …
associated with human gut microbiome variation. Murine quantitative trait loci, human twin …
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Genome-wide association studies (GWAS) have transformed our understanding of glioma
susceptibility, but individual studies have had limited power to identify risk loci. We …
susceptibility, but individual studies have had limited power to identify risk loci. We …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD) …
[HTML][HTML] A map of human genome variation from population scale sequencing
1000 Genomes Project Consortium - Nature, 2010 - ncbi.nlm.nih.gov
Abstract The 1000 Genomes Project aims to provide a deep characterisation of human
genome sequence variation as a foundation for investigating the relationship between …
genome sequence variation as a foundation for investigating the relationship between …
Pulmonary effects of maternal smoking on the fetus and child: effects on lung development, respiratory morbidities, and life long lung health
Maternal smoking during pregnancy is the largest preventable cause of abnormal in-utero
lung development. Despite well known risks, rates of smoking during pregnancy have only …
lung development. Despite well known risks, rates of smoking during pregnancy have only …
Identification of nine new susceptibility loci for endometrial cancer
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …
in developed countries. Through genome-wide association studies (GWAS), we have …