Mechanisms and consequences of intestinal dysbiosis
GA Weiss, T Hennet - Cellular and Molecular Life Sciences, 2017 - Springer
The composition of the gut microbiota is in constant flow under the influence of factors such
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …
as the diet, ingested drugs, the intestinal mucosa, the immune system, and the microbiota …
NADPH oxidases: an overview from structure to innate immunity-associated pathologies
Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …
Toll-like receptors and inflammatory bowel disease
Y Lu, X Li, S Liu, Y Zhang, D Zhang - Frontiers in immunology, 2018 - frontiersin.org
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions
of patients worldwide. Increasing evidence has recently highlighted immune-system …
of patients worldwide. Increasing evidence has recently highlighted immune-system …
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
X Wang, N Ota, P Manzanillo, L Kates, J Zavala-Solorio… - Nature, 2014 - nature.com
The connection between an altered gut microbiota and metabolic disorders such as obesity,
diabetes, and cardiovascular disease is well established,. Defects in preserving the integrity …
diabetes, and cardiovascular disease is well established,. Defects in preserving the integrity …
Functional specialization of interleukin-17 family members
Y Iwakura, H Ishigame, S Saijo, S Nakae - Immunity, 2011 - cell.com
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17)
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …
cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F …
The IL-20 subfamily of cytokines—from host defence to tissue homeostasis
Abstract The interleukin-20 (IL-20) subfamily of cytokines comprises IL-19, IL-20, IL-22, IL-24
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
and IL-26. These cytokines are all members of the larger IL-10 family, but have been …
Modulation of immune development and function by intestinal microbiota
AM Kabat, N Srinivasan, KJ Maloy - Trends in immunology, 2014 - cell.com
The immune system must constantly monitor the gastrointestinal tract for the presence of
pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal …
pathogens while tolerating trillions of commensal microbiota. It is clear that intestinal …
Interleukin 23 production by intestinal CD103+ CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense
Microbial penetration of the intestinal epithelial barrier triggers inflammatory responses that
include induction of the bactericidal C-type lectin RegIIIγ. Systemic administration of …
include induction of the bactericidal C-type lectin RegIIIγ. Systemic administration of …
Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice
Background & Aims Mice lacking the receptor Toll-like receptor 5 (TLR5-null mice), which
recognizes flagellin, have an altered intestinal microbiota composition compared with wild …
recognizes flagellin, have an altered intestinal microbiota composition compared with wild …
Inflammation triggers ILC3 patrolling of the intestinal barrier
A Jarade, Z Garcia, S Marie, A Demera, I Prinz… - Nature …, 2022 - nature.com
An orchestrated cellular network, including adaptive lymphocytes and group 3 innate
lymphoid cells (ILC3s), maintains intestinal barrier integrity and homeostasis. T cells can …
lymphoid cells (ILC3s), maintains intestinal barrier integrity and homeostasis. T cells can …