Contribution of the gut microbiome to drug disposition, pharmacokinetic and pharmacodynamic variability
The trillions of microbes that make up the gut microbiome are an important contributor to
health and disease. With respect to xenobiotics, particularly orally administered compounds …
health and disease. With respect to xenobiotics, particularly orally administered compounds …
Advances in microbiome-derived solutions and methodologies are founding a new era in skin health and care
A Gueniche, O Perin, A Bouslimani, L Landemaine… - Pathogens, 2022 - mdpi.com
The microbiome, as a community of microorganisms and their structural elements, genomes,
metabolites/signal molecules, has been shown to play an important role in human health …
metabolites/signal molecules, has been shown to play an important role in human health …
Tandem mass spectrometry molecular networking as a powerful and efficient tool for drug metabolism studies
Molecular networking (MN) has become a popular data analysis method for untargeted
mass spectrometry (MS)/MS-based metabolomics. Recently, MN has been suggested as a …
mass spectrometry (MS)/MS-based metabolomics. Recently, MN has been suggested as a …
Predictive metabolites for incident myocardial infarction: a two-step meta-analysis of individual patient data from six cohorts comprising 7897 individuals from the …
Aims Myocardial infarction (MI) is a major cause of death and disability worldwide. Most
metabolomics studies investigating metabolites predicting MI are limited by the participant …
metabolomics studies investigating metabolites predicting MI are limited by the participant …
Effects of antibiotic use on saliva antibody content and oral microbiota in Sprague Dawley rats
X Cheng, F He, M Si, P Sun, Q Chen - Frontiers in cellular and …, 2022 - frontiersin.org
Antibiotics are often used to treat systemic diseases not associated with the oral cavity. This
application of antibiotics may affect the healthy oral microbiota community, as it destroys the …
application of antibiotics may affect the healthy oral microbiota community, as it destroys the …
Chemical proportionality within molecular networks
Molecular networking of non-targeted tandem mass spectrometry data connects structurally
related molecules based on similar fragmentation spectra. Here, we report the Chem ical …
related molecules based on similar fragmentation spectra. Here, we report the Chem ical …
Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats
J Zhou, R Zhang, P Guo, P Li, X Huang, Y Wei… - Frontiers in …, 2022 - frontiersin.org
Background Intestinal microbiota has been confirmed to influencing the pharmacokinetic
processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut …
processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut …
[HTML][HTML] Dissecting the human gut microbiome to better decipher drug liability: A once-forgotten organ takes center stage
Background The gut microbiome is a diverse system within the gastrointestinal tract
composed of trillions of microorganisms (gut microbiota), along with their genomes …
composed of trillions of microorganisms (gut microbiota), along with their genomes …
Potential and challenges in application of physiologically based pharmacokinetic modeling in predicting diarrheal disease impact on oral drug pharmacokinetics
Physiologically based pharmacokinetic (PBPK) modeling is a physiologically relevant
approach that integrates drug-specific and system parameters to generate pharmacokinetic …
approach that integrates drug-specific and system parameters to generate pharmacokinetic …
[HTML][HTML] Gut microbiota and host Cyp450s co-contribute to pharmacokinetic variability in mice with non-alcoholic steatohepatitis: Effects vary from drug to drug
J Guo, Y Xu, L Chen, S Zhang, Y Liou, X Chen… - Journal of Advanced …, 2022 - Elsevier
Introduction Pharmacokinetic variability in disease state is common in clinical practice, but
its underlying mechanism remains unclear. Recently, gut microbiota has been considered to …
its underlying mechanism remains unclear. Recently, gut microbiota has been considered to …