Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project

EA Lopera-Maya, A Kurilshikov, A van der Graaf, S Hu… - Nature …, 2022 - nature.com
Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Composite trait Mendelian randomization reveals distinct metabolic and lifestyle consequences of differences in body shape

J Sulc, A Sonrel, N Mounier, C Auwerx… - Communications …, 2021 - nature.com
Obesity is a major risk factor for a wide range of cardiometabolic diseases, however the
impact of specific aspects of body morphology remains poorly understood. We combined the …

Mendelian randomization identifies the potential causal impact of dietary patterns on circulating blood metabolites

N Taba, HK Valge, A Metspalu, T Esko, JF Wilson… - Frontiers in …, 2021 - frontiersin.org
Nutrition plays an important role in the development and progress of several health
conditions, but the exact mechanism is often still unclear. Blood metabolites are likely …

Large-scale genome-wide association study of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits

S May-Wilson, N Matoba, K Wade, JJ Hottenga… - bioRxiv, 2021 - biorxiv.org
Variable preferences for different foods are among the main determinants of their intake and
are influenced by many factors, including genetics. Despite considerable twins' heritability …