Advances and limitations of drug delivery systems formulated as eye drops

C Jumelle, S Gholizadeh, N Annabi, R Dana - Journal of Controlled …, 2020 - Elsevier
Topical instillation of eye drops remains the most common and easiest route of ocular drug
administration, representing the treatment of choice for many ocular diseases. Nevertheless …

Hyaluronic acid in ocular drug delivery

X Zhang, D Wei, Y Xu, Q Zhu - Carbohydrate Polymers, 2021 - Elsevier
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

How can machine learning and multiscale modeling benefit ocular drug development?

N Wang, Y Zhang, W Wang, Z Ye, H Chen, G Hu… - Advanced Drug Delivery …, 2023 - Elsevier
The eyes possess sophisticated physiological structures, diverse disease targets, limited
drug delivery space, distinctive barriers, and complicated biomechanical processes …

Advancing the stimuli response of polymer-based drug delivery systems for ocular disease treatment

DD Nguyen, JY Lai - Polymer Chemistry, 2020 - pubs.rsc.org
The development of efficient therapies for ocular diseases remains a significant challenge
because of the static and dynamic barriers in the eye. A variety of pharmaceutical strategies …

Therapeutic contact lenses with polymeric vehicles for ocular drug delivery: a review

SW Choi, J Kim - Materials, 2018 - mdpi.com
The eye has many barriers with specific anatomies that make it difficult to deliver drugs to
targeted ocular tissues, and topical administration using eye drops or ointments usually …

A review on antifungal efficiency of plant extracts entrenched polysaccharide-based nanohydrogels

N Kaur, A Bains, R Kaushik, SB Dhull, F Melinda… - Nutrients, 2021 - mdpi.com
Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi,
which becomes more severe if the infection occurs on the third layer of the skin. Azole …

Gellan gum in drug delivery applications

M Milivojevic, I Pajic-Lijakovic, B Bugarski… - … polysaccharides in drug …, 2019 - Elsevier
The different techniques that enable drug delivery in the desired manner are constantly
investigated and developed to enhance patient compliance and drug efficiency and to …

Cyclodextrin regulated natural polysaccharide hydrogels for biomedical applications-a review

S Wang, Y Wei, Y Wang, Y Cheng - Carbohydrate Polymers, 2023 - Elsevier
Cyclodextrin and its derivative (CDs) are natural building blocks for linking with other
components to afford functional biomaterials. Hydrogels are polymer network systems that …

Hyaluronic acid: Its versatile use in ocular drug delivery with a specific focus on hyaluronic acid-based polyelectrolyte complexes

S Casey-Power, R Ryan, G Behl, P McLoughlin… - Pharmaceutics, 2022 - mdpi.com
Extensive research is currently being conducted into novel ocular drug delivery systems
(ODDS) that are capable of surpassing the limitations associated with conventional …

[HTML][HTML] Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies

BR Giri, D Jakka, MA Sandoval, VR Kulkarni, Q Bao - Pharmaceutics, 2024 - mdpi.com
Eye disorders affect a substantial portion of the global population, yet the availability of
efficacious ophthalmic drug products remains limited. This can be partly ascribed to a …