Synthesis, structure, properties, and applications of bimetallic nanoparticles of noble metals

K Loza, M Heggen, M Epple - Advanced functional materials, 2020‏ - Wiley Online Library
Bimetallic nanoparticles of noble metals are of high interest in imaging, biomedical devices,
including nanomedicine, and heterogeneous catalysis. Synthesis, properties …

The why and how of ultrasmall nanoparticles

M Epple, VM Rotello, K Dawson - Accounts of Chemical Research, 2023‏ - ACS Publications
Conspectus In this Account, we describe our research into ultrasmall nanoparticles,
including their unique properties, and outline some of the new opportunities they offer. We …

Transport of ultrasmall gold nanoparticles (2 nm) across the blood–brain barrier in a six-cell brain spheroid model

V Sokolova, G Mekky, SB van der Meer, MC Seeds… - Scientific Reports, 2020‏ - nature.com
The blood–brain barrier (BBB) is an efficient barrier for molecules and drugs. Multicellular
3D spheroids display reproducible BBB features and functions. The spheroids used here …

Ultrasmall gold nanoparticles (2 nm) can penetrate and enter cell nuclei in an in vitro 3D brain spheroid model

V Sokolova, G Nzou, SB van der Meer, T Ruks… - Acta biomaterialia, 2020‏ - Elsevier
The neurovascular unit (NVU) is a complex functional and anatomical structure composed of
endothelial cells and their blood-brain barrier (BBB) forming tight junctions. It represents an …

CuAAC ensembled 1, 2, 3-triazole linked nanogels for targeted drug delivery: A review

G Singh, A Majeed, R Singh, N George, G Singh… - RSC …, 2023‏ - pubs.rsc.org
Copper (I) catalyzed alkyne azide cycloaddition (CuAAC), the quintessential example of
'click chemistry', provides an adaptable and adequate platform for the synthesis of nanogels …

Uptake of functional ultrasmall gold nanoparticles in 3D gut cell models

V Sokolova, JF Ebel, S Kollenda, K Klein, B Kruse… - Small, 2022‏ - Wiley Online Library
Ultrasmall gold nanoparticles (2 nm) easily penetrate the membranes of intestinal murine
epithelial cells (MODE‐K) and colorectal cancer cells (CT‐26). They are also taken up by 3D …

The application of ultrasmall gold nanoparticles (2 nm) functionalized with doxorubicin in three-dimensional normal and glioblastoma organoid models of the blood …

K Kostka, V Sokolova, A El-Taibany, B Kruse, D Porada… - Molecules, 2024‏ - mdpi.com
Among brain tumors, glioblastoma (GBM) is very challenging to treat as chemotherapeutic
drugs can only penetrate the brain to a limited extent due to the blood–brain barrier (BBB) …

Ultrastructure and surface composition of glutathione-terminated ultrasmall silver, gold, platinum, and alloyed silver–platinum nanoparticles (2 nm)

N Wolff, K Loza, M Heggen, T Schaller… - Inorganic …, 2023‏ - ACS Publications
Alloyed ultrasmall silver–platinum nanoparticles (molar ratio Ag: Pt= 50: 50) were prepared
and compared to pure silver, platinum, and gold nanoparticles, all with a metallic core …

Specific Instantaneous Detection of Klebsiella pneumoniae for UTI Diagnosis with a Plasmonic Gold Nanoparticle Conjugated Aptasensor

A Deb, M Gogoi, TK Mandal, S Sinha… - ACS Applied Bio …, 2023‏ - ACS Publications
Urinary tract infection (UTI), which can be caused by various pathogens, if not detected at an
early stage can be fatal. It is essential to identify the specific pathogen responsible for UTI for …

Click chemistry in the electrochemical systems: Toward the architecture of electrochemical (bio) sensors

KE Sekhosana, SA Majeed, U Feleni - Coordination Chemistry Reviews, 2023‏ - Elsevier
Click chemistry is considered one of the most powerful tools used to design a variety of
compounds or complexes including biomolecules, polymers, organometallics, organics …