MYC and therapy resistance in cancer: risks and opportunities
G Donati, B Amati - Molecular oncology, 2022 - Wiley Online Library
The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …
Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress
Due to the overexpression or amplification of human epidermal growth factor receptor 2
(HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on …
(HER2) with poor prognosis in a myriad of human tumors, recent studies have focused on …
Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche
Multiple myeloma is largely incurable, despite development of therapies that target myeloma
cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells …
cell-intrinsic pathways. Disease relapse is thought to originate from dormant myeloma cells …
VEGF drives cancer-initiating stem cells through VEGFR-2/Stat3 signaling to upregulate Myc and Sox2
Vascular endothelial growth factor-A (VEGF), a potent angiogenic factor, is also implicated in
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
self-renewal in several normal tissue types. VEGF has been shown to drive malignant stem …
Inhibition of STAT3, FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and
therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer …
therapy resistance. In this study, we evaluated the effects of Shikonin (Shk) on breast cancer …
MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis
Mesenchymal stem/stromal cells (MSCs) are progenitor cells shown to participate in breast
tumor stroma formation and to promote metastasis. Despite expanding knowledge of their …
tumor stroma formation and to promote metastasis. Despite expanding knowledge of their …
Breast cancer stem cell: the roles and therapeutic implications
F Yang, J Xu, L Tang, X Guan - Cellular and Molecular Life Sciences, 2017 - Springer
Breast cancers have been increasingly recognized as malignancies displaying frequent
inter-and intra-tumor heterogeneity. This heterogeneity is represented by diverse subtypes …
inter-and intra-tumor heterogeneity. This heterogeneity is represented by diverse subtypes …
The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer
Y Pang, G Bai, J Zhao, X Wei, R Li, J Li, S Hu… - Journal of translational …, 2022 - Springer
Background Endometrial cancer (EC) is the most common gynecological malignancy in
developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported …
developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported …
Overcoming tamoxifen resistance of human breast cancer by targeted gene silencing using multifunctional pRNA nanoparticles
Most breast cancers express estrogen receptor (ER) α, and the antiestrogen drug tamoxifen
has been widely used for their treatment. Unfortunately, up to half of all ERα-positive tumors …
has been widely used for their treatment. Unfortunately, up to half of all ERα-positive tumors …
Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
Background Mesenchymal stromal cells isolated from bone marrow (MSC) represent an
attractive source of adult stem cells for regenerative medicine. However, thorough research …
attractive source of adult stem cells for regenerative medicine. However, thorough research …