Retinoic acid (RA), a metabolite of retinol (vitamin A), functions as a ligand for nuclear RA
receptors (RARs) that regulate development of chordate animals. RA-RARs can activate or …

In mammalian cells, two cellular organelles, mitochondria and peroxisomes, share the ability
to degrade fatty acid chains. Although each organelle harbors its own fatty acid β-oxidation …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

Vitamin A (retinol) is an important nutrient for embryonic development and adult health. Early
studies identified retinoic acid (RA) as a metabolite of retinol, however, its importance was …

Circadian and circannual cycles trigger physiological changes whose reflection on human
transcriptomes remains largely uncharted. We used the time and season of death of 932 …

Retinoic acid (RA), derived from vitamin A, is a major teratogen, clinically recognized in
1983. Identification of its natural presence in the embryo and dissection of its molecular …

Substantial experimental and epidemiological data have highlighted the interplay between
nutritional and genetic factors in the development of congenital heart defects. Retinoic acid …

A small number of signaling pathways are used repeatedly during organogenesis, and they
can have drastically different effects on the same population of cells depending on the …

Retinoids are a group of vitamin A-related chemicals that are essential to chordate
mammals. They regulate a number of basic processes, including embryogenesis and vision …

Retinoic acid (RA) functions as an essential signal for development of the vertebrate eye by
controlling the transcriptional regulatory activity of RA receptors (RARs). During eye …