The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Acute myeloid leukaemia (AML) represents a set of heterogeneous myeloid malignancies,
and hallmarks include mutations in epigenetic modifiers, transcription factors and kinases …

Genome-wide association studies of neurological diseases have identified thousands of
variants associated with disease phenotypes. However, most of these variants do not alter …

Super-enhancers are important for controlling and defining the expression of cell-specific
genes. With research on human disease and biological processes, human H3K27ac ChIP …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of
alterations in transcription factors, epigenetic regulators and signaling molecules. To …

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an
increased risk of myeloid malignancies. We performed an integrative characterization of …

Recent studies suggest that targeting transcriptional machinery can lead to potent and
selective anticancer effects in cancers dependent on high and constant expression of certain …

Cancer is fueled by the aberrant activity of oncogenic and tumor suppressive pathways.
Transcriptional dysregulation of these pathways play a major role both in the genesis and …

Blocked cellular differentiation is a central pathologic feature of the myeloid malignancies,
myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Treatment regimens …