Akt in cancer: Mediator and more
Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …
Targeting Akt in cancer for precision therapy
H Hua, H Zhang, J Chen, J Wang, J Liu… - Journal of Hematology & …, 2021 - Springer
Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
Infant high-grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes
M Clarke, A Mackay, B Ismer, JC Pickles… - Cancer discovery, 2020 - AACR
Infant high-grade gliomas appear clinically distinct from their counterparts in older children,
indicating that histopathologic grading may not accurately reflect the biology of these tumors …
indicating that histopathologic grading may not accurately reflect the biology of these tumors …
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are
considered as a global health challenge. Despite many progresses in therapeutic methods …
considered as a global health challenge. Despite many progresses in therapeutic methods …
Akt: a key transducer in cancer
Growth factor signaling plays a pivotal role in diverse biological functions, such as cell
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
growth, apoptosis, senescence, and migration and its deregulation has been linked to …
Distinct functions of AKT isoforms in breast cancer: a comprehensive review
N Hinz, M Jücker - Cell Communication and Signaling, 2019 - Springer
Background AKT, also known as protein kinase B, is a key element of the PI3K/AKT
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
signaling pathway. Moreover, AKT regulates the hallmarks of cancer, eg tumor growth …
Interstitial leukocyte migration and immune function
The trafficking of leukocytes into and within lymphoid and peripheral tissues is central to
immune cell development, immunosurveillance and effector function. Interstitial leukocyte …
immune cell development, immunosurveillance and effector function. Interstitial leukocyte …
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt
Both pro-and antioncogenic properties have been attributed to EphA2 kinase. We report that
a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in …
a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in …
Wnt Signaling in vascular eye diseases
The Wnt signaling pathway plays a pivotal role in vascular morphogenesis in various organs
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
including the eye. Wnt ligands and receptors are key regulators of ocular angiogenesis both …
PKB/Akt–dependent regulation of cell motility
G Xue, BA Hemmings - Journal of the National Cancer Institute, 2013 - academic.oup.com
The prosurvival activity of phosphoinositide 3 kinase (PI3K)/Akt (also known as protein
kinase B, PKB) pathway has been investigated in great detail in human physiology and …
kinase B, PKB) pathway has been investigated in great detail in human physiology and …