Medicinal inorganic chemistry offers additional opportunities for the design of therapeutic
agents not accessible to organic compounds. 1− 3 The wide range of coordination numbers …

Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

Increasing numbers of DNA structures are being revealed using biophysical, spectroscopic
and genomic methods. The diversity of transition metal complexes is also growing, as the …

The nucleus is considered the ideal target for anti‐tumor therapy because DNA and some
enzymes in the nucleus are the main causes of cell canceration and malignant proliferation …

From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

Guanine rich regions of oligonucleotides fold into quadruple-stranded structures called G-
quadruplexes (G4s). Increasing evidence suggests that these G4 structures form in vivo and …

Although cisplatin and its analogues have been widely utilized as anticancer metallodrugs
in clinics, their serious side effects and damage to normal tissues cannot be avoided …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

Salen is a common abbreviation for tetradentate N 2 O 2 bis-Schiff base bis-phenolate
ligands. Due to the ease of their synthesis, rich coordination chemistry and photophysical …